Mtfp1 mitochondrial fission process 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtfp1provided by MGI
Official Full Name: mitochondrial fission process 1provided by MGI
Primary source: MGI:MGI:1916686
See related: Ensembl:ENSMUSG00000004748 AllianceGenome:MGI:1916686
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mtp18; 1700020C11Rik; 2610507A21Rik
Summary: Acts upstream of or within apoptotic process and mitochondrion organization. Located in mitochondrion. Is expressed in pancreas epithelium. Orthologous to human MTFP1 (mitochondrial fission process 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in heart adult (RPKM 50.0), frontal lobe adult (RPKM 26.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.87 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (4041481..4045431, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (4091481..4095431, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
Title: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.
Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis.
Title: Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis.
Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure.
Title: Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure.
the results suggest that miR-668 is induced via HIF-1 in ischemic AKI and that, upon induction, miR-668 represses MTP18 to preserve mitochondrial dynamics for renal tubular cell survival and kidney protection.
Title: MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury.
Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission.
Title: Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission.
Data provide direct evidence for cell survival upon mTOR inhibition through mitochondrial hyperfusion employing MTFP1 as a critical effector of mTORC1 to govern cell fate decisions.
Title: mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial membrane organization	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: mitochondrial fission process protein 1

Names: mitochondrial 18 kDa protein; mitochondrial fission protein MTP18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.