Slc25a28 solute carrier family 25, member 28 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a28provided by MGI
Official Full Name: solute carrier family 25, member 28provided by MGI
Primary source: MGI:MGI:2180509
See related: Ensembl:ENSMUSG00000040414 AllianceGenome:MGI:2180509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mfrn2; Mrs3/4
Summary: Enables ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Predicted to act upstream of or within ion transport and iron ion homeostasis. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; immune system; liver; and lung. Orthologous to human SLC25A28 (solute carrier family 25 member 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 37.3), adrenal adult (RPKM 28.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.67 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (43652240..43663320, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (43663801..43675006, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis.
Title: Microglial SLC25A28 Deficiency Ameliorates the Brain Injury After Intracerebral Hemorrhage in Mice by Restricting Aerobic Glycolysis.
Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.
Title: Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis.
The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
Title: The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
The cis-regulatory modules (CRMs) that control expression of the Mfrn genes, were mapped.
Title: Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.
Mitoferrin 1 and mitoferrin 2 contribute to mitochondrial iron delivery in a variety of cells.
Title: Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (4) 1 citation

General gene information

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Markers

RH125277 (e-PCR)
- UniSTS:162099

NoName (e-PCR)
- UniSTS:237944

NoName (e-PCR)
- UniSTS:237945

MARC_3591-3592:966880954:1 (e-PCR)
- UniSTS:269280

Slc25a28 (e-PCR), detects polymorphism
- UniSTS:547047

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferrous iron transmembrane transporter activity	EXP Inferred from Experiment more info	PubMed
enables ferrous iron transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in iron import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitoferrin-2

Names: mitochondrial RNA-splicing protein 3/4 homolog; mitochondrial iron transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356944.1 → NP_001343873.1 mitoferrin-2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1 The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC138790, AF377993, BE849400

Conserved Domains (1) summary

pfam00153
Location:1 → 66

Mito_carr; Mitochondrial carrier protein
NM_145156.1 → NP_660138.1 mitoferrin-2 isoform 1

See identical proteins and their annotated locations for NP_660138.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC138790, AF377994, BE849400

Consensus CDS

CCDS29834.1

UniProtKB/Swiss-Prot

Q8K4J8, Q8K4J9, Q8R0Z5, Q8R578

Related

ENSMUSP00000036913.8, ENSMUST00000046038.9

Conserved Domains (1) summary

pfam00153
Location:71 → 161

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

43652240..43663320 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318202.3 → XP_017173691.1 mitoferrin-2 isoform X1

Conserved Domains (1) summary

pfam00153
Location:76 → 160

Mito_carr; Mitochondrial carrier protein
XM_006527097.3 → XP_006527160.1 mitoferrin-2 isoform X2

Conserved Domains (1) summary

pfam00153
Location:4 → 82

Mito_carr; Mitochondrial carrier protein