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    TEX10 testis expressed 10 [ Homo sapiens (human) ]

    Gene ID: 54881, updated on 7-Apr-2024

    Summary

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    Official Symbol
    TEX10provided by HGNC
    Official Full Name
    testis expressed 10provided by HGNC
    Primary source
    HGNC:HGNC:25988
    See related
    Ensembl:ENSG00000136891 MIM:616717; AllianceGenome:HGNC:25988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ipi1; bA208F1.2
    Summary
    Located in mitochondrion and nucleoplasm. Part of MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 16.8), placenta (RPKM 10.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9q31.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (100302084..100352942, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (112473720..112524578, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (103064366..103115224, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene inversin Neighboring gene Sharpr-MPRA regulatory region 13033 Neighboring gene Nanog homeobox pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28722 Neighboring gene uncharacterized LOC124902235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:103046218-103046718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:103046719-103047219 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:103103415-103103914 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:103114917-103115551 Neighboring gene uncharacterized LOC105376177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28723 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:103131616-103131808 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:103155294-103155664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20137 Neighboring gene MSANTD3-TMEFF1 readthrough Neighboring gene Myb/SANT DNA binding domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway. Xiang X, et al. Oncol Rep, 2019 Dec. PMID 31638260, Free PMC Article
    2. Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma. Xiang X, et al. Cell Cycle, 2018. PMID 30045663, Free PMC Article
    3. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. Yoshitake H, et al. Cancer Biomark, 2012-2013. PMID 23481573
    4. LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer. Liang JH, et al. Bioengineered, 2022 Feb. PMID 35156514, Free PMC Article
    5. TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6. Luo S, et al. J Immunol Res, 2021. PMID 34966825, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer.
      Title: LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer.
    2. TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6.
      Title: TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6.
    3. LncRNA GATA3AS1miR30b5pTex10 axis modulates tumorigenesis in pancreatic cancer.
      Title: LncRNA GATA3‑AS1‑miR‑30b‑5p‑Tex10 axis modulates tumorigenesis in pancreatic cancer.
    4. Elevated expression of TEX10 was positively associated with malignancy and with epithelialmesenchymal transition (EMT)associated mesenchymal markers in human esophageal squamous cell carcinoma (ESCC) specimens. Study revealed that TEX10 promotes stem celllike features and plays an essential role in regulating EMT via the activation of Wnt/betacatenin signaling in ESCC.
      Title: Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway.
    5. Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
      Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
    6. Tex10 plays a potent carcinogenic role in hepatocellular carcinoma tumorigenesis by maintaining cancer stem cell properties through activation of the STAT3 signaling pathway and promoting chemo-resistance.
      Title: Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma.
    7. Tex10 is a core component of the pluripotency network.
      Title: Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming.
    8. Data suggest that TEX101 is a cancer-related protein and may be useful as a marker for prognosis/diagnosis of and neck squamous cell carcinomas (HNSCC).
      Title: Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma.
    9. These data define the PELP1-TEX10-WDR18 complex as a regulator of ribosome biogenesis and suggests that its SUMO-controlled distribution coordinates the rate of ribosome formation.
      Title: The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20287, FLJ31157, FLJ34350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-expressed protein 10
    Names
    testis expressed gene 10
    testis-expressed sequence 10 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161584.2 → NP_001155056.1  testis-expressed protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001155056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at an alternate AUG and result in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AA436854, AK302619
      Consensus CDS
      CCDS55330.1
      UniProtKB/TrEMBL
      B4DQR0
      Related
      ENSP00000444555.1, ENST00000535814.5
      Conserved Domains (1) summary
      pfam12333
      Location:135 → 238
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

    2. NM_017746.4 → NP_060216.2  testis-expressed protein 10 isoform 1

      See identical proteins and their annotated locations for NP_060216.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA436854, AB060968, BC030652, BP336313
      Consensus CDS
      CCDS6748.1
      UniProtKB/Swiss-Prot
      B4DYV2, Q5T722, Q5T723, Q8NCN8, Q8TDY0, Q9NXF1
      UniProtKB/TrEMBL
      B4DQR0
      Related
      ENSP00000364037.4, ENST00000374902.9
      Conserved Domains (1) summary
      pfam12333
      Location:132 → 235
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      100302084..100352942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518798.3 → XP_011517100.1  testis-expressed protein 10 isoform X1

      UniProtKB/TrEMBL
      B4DQR0
      Conserved Domains (1) summary
      pfam12333
      Location:132 → 235
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

    2. XM_047423523.1 → XP_047279479.1  testis-expressed protein 10 isoform X2

    3. XM_047423524.1 → XP_047279480.1  testis-expressed protein 10 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      112473720..112524578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363149.1 → XP_054219124.1  testis-expressed protein 10 isoform X1

    2. XM_054363150.1 → XP_054219125.1  testis-expressed protein 10 isoform X2

    3. XM_054363151.1 → XP_054219126.1  testis-expressed protein 10 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXF1.2 GenPept UniProtKB/Swiss-Prot:Q9NXF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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