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    STX17 syntaxin 17 [ Homo sapiens (human) ]

    Gene ID: 55014, updated on 11-Apr-2024

    Summary

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    Official Symbol
    STX17provided by HGNC
    Official Full Name
    syntaxin 17provided by HGNC
    Primary source
    HGNC:HGNC:11432
    See related
    Ensembl:ENSG00000136874 MIM:604204; AllianceGenome:HGNC:11432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables SNAP receptor activity; SNARE binding activity; and protein phosphatase binding activity. Involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Acts upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum-Golgi intermediate compartment; and mitochondria-associated endoplasmic reticulum membrane. Part of SNARE complex. Colocalizes with HOPS complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.7), skin (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9q31.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (99906654..99974534)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (112078304..112146158)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (102668936..102736816)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:102584885-102585397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:102595258-102596457 Neighboring gene nuclear receptor subfamily 4 group A member 3 Neighboring gene STX17 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28716 Neighboring gene NANOG hESC enhancer GRCh37_chr9:102678782-102679392 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene uncharacterized LOC105376176 Neighboring gene UPF3A pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation of STX17 (syntaxin 17) controls autophagosome maturation. Shen Q, et al. Autophagy, 2021 May. PMID 32264736, Free PMC Article
    2. A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes. Vats S, et al. Mol Biol Cell, 2019 Aug 1. PMID 31188703, Free PMC Article
    3. Regulation of Syntaxin 17 during Autophagosome Maturation. Viret C, et al. Trends Cell Biol, 2019 Jan. PMID 30415939
    4. The cytotoxicity of coxsackievirus B3 is associated with a blockage of autophagic flux mediated by reduced syntaxin 17 expression. Tian L, et al. Cell Death Dis, 2018 Feb 14. PMID 29445155, Free PMC Article
    5. SNARE priming is essential for maturation of autophagosomes but not for their formation. Abada A, et al. Proc Natl Acad Sci U S A, 2017 Nov 28. PMID 29138318, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion.
      Title: Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion.
    2. The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
      Title: The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
    3. ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
      Title: ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
    4. Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
      Title: Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.
    5. Long non-coding RNA XIST confers aggressive progression via miR-361-3p/STX17 in retinoblastoma cells.
      Title: Long non-coding RNA XIST confers aggressive progression via miR-361-3p/STX17 in retinoblastoma cells.
    6. A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
      Title: A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.
    7. Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p.
      Title: Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p.
    8. DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
      Title: DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
    9. Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
      Title: Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
    10. EACC affects the translocation of SNAREs Stx17 and SNAP29 on autophagosomes without impeding the completion of autophagosomes. EACC treatment also reduces the interaction of Stx17 with the HOPS subunit VPS33A and the cognate lysosomal R-SNARE VAMP8.
      Title: A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20651, MGC102796, MGC126613, MGC126615

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome membrane docking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum-Golgi intermediate compartment organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ER to Golgi transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HOPS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in smooth endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017919.3 → NP_060389.2  syntaxin-17

      See identical proteins and their annotated locations for NP_060389.2

      Status: VALIDATED

      Source sequence(s)
      AI375996, AL358937, BC101566, DC318495
      Consensus CDS
      CCDS6745.1
      UniProtKB/Swiss-Prot
      P56962, Q4VXC2
      UniProtKB/TrEMBL
      B3KTA5, Q2TAB5
      Related
      ENSP00000259400.6, ENST00000259400.11
      Conserved Domains (2) summary
      COG5325
      Location:2 → 228
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15846
      Location:162 → 223
      SNARE_syntaxin17; SNARE motif of syntaxin 17

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      99906654..99974534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423551.1 → XP_047279507.1  syntaxin-17 isoform X1

      UniProtKB/Swiss-Prot
      P56962, Q4VXC2
      Related
      ENSP00000433484.1, ENST00000534052.1

    2. XM_011518821.4 → XP_011517123.1  syntaxin-17 isoform X1

      See identical proteins and their annotated locations for XP_011517123.1

      UniProtKB/Swiss-Prot
      P56962, Q4VXC2
      UniProtKB/TrEMBL
      B3KTA5, Q2TAB5
      Conserved Domains (2) summary
      COG5325
      Location:2 → 228
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15846
      Location:162 → 223
      SNARE_syntaxin17; SNARE motif of syntaxin 17

    3. XM_047423553.1 → XP_047279509.1  syntaxin-17 isoform X3

      Related
      ENSP00000436666.1, ENST00000524405.5

    4. XM_011518820.4 → XP_011517122.1  syntaxin-17 isoform X1

      See identical proteins and their annotated locations for XP_011517122.1

      UniProtKB/Swiss-Prot
      P56962, Q4VXC2
      UniProtKB/TrEMBL
      B3KTA5, Q2TAB5
      Conserved Domains (2) summary
      COG5325
      Location:2 → 228
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15846
      Location:162 → 223
      SNARE_syntaxin17; SNARE motif of syntaxin 17

    5. XM_047423552.1 → XP_047279508.1  syntaxin-17 isoform X2

    6. XM_011518823.4 → XP_011517125.1  syntaxin-17 isoform X2

      See identical proteins and their annotated locations for XP_011517125.1

      Conserved Domains (1) summary
      cd15846
      Location:73 → 134
      SNARE_syntaxin17; SNARE motif of syntaxin 17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      112078304..112146158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363201.1 → XP_054219176.1  syntaxin-17 isoform X1

      UniProtKB/Swiss-Prot
      P56962, Q4VXC2

    2. XM_054363199.1 → XP_054219174.1  syntaxin-17 isoform X1

      UniProtKB/Swiss-Prot
      P56962, Q4VXC2

    3. XM_054363200.1 → XP_054219175.1  syntaxin-17 isoform X1

      UniProtKB/Swiss-Prot
      P56962, Q4VXC2

    4. XM_054363202.1 → XP_054219177.1  syntaxin-17 isoform X2

    5. XM_054363203.1 → XP_054219178.1  syntaxin-17 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56962.2 GenPept UniProtKB/Swiss-Prot:P56962

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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