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    CPXM2 carboxypeptidase X, M14 family member 2 [ Homo sapiens (human) ]

    Gene ID: 119587, updated on 11-Jun-2021

    Summary

    Official Symbol
    CPXM2provided by HGNC
    Official Full Name
    carboxypeptidase X, M14 family member 2provided by HGNC
    Primary source
    HGNC:HGNC:26977
    See related
    Ensembl:ENSG00000121898 MIM:617348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPX2; UNQ676
    Expression
    Broad expression in urinary bladder (RPKM 10.5), fat (RPKM 8.3) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CPXM2 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (123745636..123944094, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125505155..125651323, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 26 Neighboring gene uncharacterized LOC105378532 Neighboring gene uncharacterized LOC105378533 Neighboring gene uncharacterized LOC105378534 Neighboring gene uncharacterized LOC107984128 Neighboring gene uncharacterized LOC107984276 Neighboring gene YBX2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
    GeneReviews: Not available
    Genome-wide association study of smoking behaviours in patients with COPD.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    inactive carboxypeptidase-like protein X2
    Names
    4632435C11Rik
    carboxypeptidase Hlo
    carboxypeptidase X (M14 family), member 2
    carboxypeptidase-like protein X2
    cytosolic carboxypeptidase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052814.1 RefSeqGene

      Range
      57288..203456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198148.3NP_937791.2  inactive carboxypeptidase-like protein X2 precursor

      See identical proteins and their annotated locations for NP_937791.2

      Status: VALIDATED

      Source sequence(s)
      AC009987, AY358565
      Consensus CDS
      CCDS7637.1
      UniProtKB/Swiss-Prot
      Q8N436
      Related
      ENSP00000241305.3, ENST00000241305.4
      Conserved Domains (4) summary
      cd03869
      Location:314639
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:643718
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:138293
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:137292
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      123745636..123944094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015673.1XP_016871162.1  inactive carboxypeptidase-like protein X2 isoform X3

      Conserved Domains (4) summary
      cd03869
      Location:205530
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:534609
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:29184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:28183
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. XM_011539285.2XP_011537587.1  inactive carboxypeptidase-like protein X2 isoform X3

      Conserved Domains (4) summary
      cd03869
      Location:205530
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:534609
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:29184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:28183
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. XM_011539286.1XP_011537588.1  inactive carboxypeptidase-like protein X2 isoform X4

      Conserved Domains (4) summary
      cd03869
      Location:87412
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:416491
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:166
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:165
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. XM_017015674.1XP_016871163.1  inactive carboxypeptidase-like protein X2 isoform X5

    5. XM_011539283.2XP_011537585.1  inactive carboxypeptidase-like protein X2 isoform X2

      Conserved Domains (4) summary
      cd03869
      Location:314639
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      smart00231
      Location:138293
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:137292
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21470
      Location:643674
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    6. XM_005269528.3XP_005269585.1  inactive carboxypeptidase-like protein X2 isoform X1

      Conserved Domains (4) summary
      cd03869
      Location:314639
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:643678
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:138293
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:137292
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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