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    PLXDC2 plexin domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 84898, updated on 5-Sep-2021

    Summary

    Official Symbol
    PLXDC2provided by HGNC
    Official Full Name
    plexin domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:21013
    See related
    Ensembl:ENSG00000120594 MIM:606827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEM7R
    Expression
    Ubiquitous expression in gall bladder (RPKM 10.7), lung (RPKM 7.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLXDC2 in Genome Data Viewer
    Location:
    10p12.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (19816215..20289856)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (20105361..20578785)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MT-ND2 pseudogene 16 Neighboring gene RNA, U6 small nuclear 1212, pseudogene Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 1 Neighboring gene microRNA 4675

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
    GeneReviews: Not available
    Genome-wide association study of diabetic retinopathy in a Taiwanese population.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ14623

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    plexin domain-containing protein 2
    Names
    1200007L24Rik
    tumor endothelial marker 7-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282736.2NP_001269665.1  plexin domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001269665.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC067743, AI311457, AL353147, AL353790, AY358486, BC012885
      Consensus CDS
      CCDS60497.1
      UniProtKB/Swiss-Prot
      Q6UX71
      Related
      ENSP00000366450.3, ENST00000377242.7
      Conserved Domains (2) summary
      pfam01437
      Location:278323
      PSI; Plexin repeat
      cl02648
      Location:142233
      NIDO; Nidogen-like
    2. NM_032812.9NP_116201.7  plexin domain-containing protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_116201.7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC067743, AI311457, AL353147, AL353790, AY358486
      Consensus CDS
      CCDS7132.1
      UniProtKB/Swiss-Prot
      Q6UX71
      Related
      ENSP00000366460.3, ENST00000377252.5
      Conserved Domains (2) summary
      pfam01437
      Location:327372
      PSI; Plexin repeat
      cl02648
      Location:191282
      NIDO; Nidogen-like

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      19816215..20289856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519750.2XP_011518052.1  plexin domain-containing protein 2 isoform X1

      Conserved Domains (2) summary
      pfam01437
      Location:327372
      PSI; Plexin repeat
      cl02648
      Location:191282
      NIDO; Nidogen-like
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