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    ARG3 ornithine carbamoyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853357, updated on 11-Apr-2024

    Summary

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    Gene symbol
    ARG3
    Gene description
    ornithine carbamoyltransferase
    Primary source
    SGD:S000003624
    Locus tag
    YJL088W
    See related
    AllianceGenome:SGD:S000003624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ornithine carbamoyltransferase activity. Involved in arginine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (268799..269815)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein kinase activating protein DPB11 Neighboring gene Sip4p Neighboring gene tRNA ligase Neighboring gene GTP-Rho binding exocyst subunit EXO70

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The promoter region of the arg3 gene in Saccharomyces cerevisiae: nucleotide sequence and regulation in an arg3-lacZ gene fusion. Crabeel M, et al. EMBO J, 1983. PMID 11894927, Free PMC Article
    2. In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 4. The channeling of carbamylphosphate to aspartate transcarbamylase and its partition in the pyrimidine and arginine pathways. Penverne B, et al. Arch Biochem Biophys, 1994 Feb 15. PMID 8117117
    3. Cloning arg3, the gene for ornithine carbamoyltransferase from Saccharomyces cerevisiae: expression in Escherichia coli requires secondary mutations; production of plasmid beta-lactamase in yeast. Crabeel M, et al. Proc Natl Acad Sci U S A, 1981 Aug. PMID 7029528, Free PMC Article
    4. Purification and characterization of ornithine transcarbamoylase from Saccharomyces cerevisiae. Eisenstein E, et al. J Biol Chem, 1984 Apr 25. PMID 6370999
    5. Expression of human alpha 1-antitrypsin cDNA in the yeast Saccharomyces cerevisiae. Cabezón T, et al. Proc Natl Acad Sci U S A, 1984 Nov. PMID 6208552, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxyl- or carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ornithine carbamoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine carbamoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ornithine carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in arginine biosynthetic process via ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in citrulline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ornithine carbamoyltransferase
    NP_012447.1
    • Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      268799..269815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181521.1 → NP_012447.1  TPA: ornithine carbamoyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW96, P05150
      UniProtKB/TrEMBL
      A0A7I9F4T9, A6ZPN7, B3LQ25, C7GR26, C8ZBC5, G2WGT0, N1NZT4
      Conserved Domains (1) summary
      cl39061
      Location:12 → 329
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05150.1

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