Prdx5 peroxiredoxin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prdx5provided by MGI
Official Full Name: peroxiredoxin 5provided by MGI
Primary source: MGI:MGI:1859821
See related: Ensembl:ENSMUSG00000024953 AllianceGenome:MGI:1859821
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PLP; AOPP; PrxV; Pmp20; Prdx6; AOEB166
Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites may result in use of alternate in-frame translation start codons that generate alternate isoforms that are targeted to the mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov 2017]
Expression: Ubiquitous expression in kidney adult (RPKM 737.0), heart adult (RPKM 197.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.08 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6884065..6887474, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6906697..6910106, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer.
Title: Identification of PRDX5 as A Target for The Treatment of Castration-Resistant Prostate Cancer.
Mitochondrial peroxiredoxin 5 overexpression suppresses insulin-induced adipogenesis by downregulating the phosphorylation of p38.
Title: Mitochondrial peroxiredoxin 5 overexpression suppresses insulin-induced adipogenesis by downregulating the phosphorylation of p38.
Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration.
Title: Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration.
Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice.
Title: Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice.
Antioxidant enzyme peroxiredoxin 5 regulates cyst growth and ciliogenesis via modulating Plk1 stability.
Title: Antioxidant enzyme peroxiredoxin 5 regulates cyst growth and ciliogenesis via modulating Plk1 stability.
Macrophage peroxiredoxin 5 deficiency promotes lung cancer progression via ROS-dependent M2-like polarization.
Title: Macrophage peroxiredoxin 5 deficiency promotes lung cancer progression via ROS-dependent M2-like polarization.
Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
Title: Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Title: Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3.
Title: Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3.
Brucella infection increased Prdx5 expression in primary macrophage and mice.
Title: Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prdx6 (e-PCR), detects polymorphism
- UniSTS:166202

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase III transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables peroxynitrite reductase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	ISO Inferred from Sequence Orthology more info
enables thioredoxin-dependent peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NADPH oxidation	ISO Inferred from Sequence Orthology more info
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in reactive nitrogen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptosis involved in tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxiredoxin-5, mitochondrial

Names: antioxidant enzyme B166; liver tissue 2D-page spot 2D-0014IV; peroxiredoxin 6; peroxiredoxin V; peroxisomal antioxidant enzyme; peroxisomal membrane protein 20; thioredoxin peroxidase PMP20; thioredoxin reductase; thioredoxin-dependent peroxiredoxin 5

NP_001345373.1

EC 1.11.1.24

NP_036151.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358444.1 → NP_001345373.1 peroxiredoxin-5, mitochondrial isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus than isoform 1.

Source sequence(s)

AC120557

UniProtKB/TrEMBL

A0A494BAZ4

Related

ENSMUSP00000158249.2, ENSMUST00000238095.2

Conserved Domains (1) summary

cd03013
Location:54 → 155

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...
NM_012021.3 → NP_036151.1 peroxiredoxin-5, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_036151.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA208558, AC120557, AK003332, AK009858

Consensus CDS

CCDS29507.1

UniProtKB/Swiss-Prot

P99029, Q9QX45, Q9QZ75

UniProtKB/TrEMBL

Q3U7H9

Related

ENSMUSP00000025904.6, ENSMUST00000025904.12

Conserved Domains (1) summary

cd03013
Location:54 → 208

PRX5_like; Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 ...