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    Ctsf cathepsin F [ Mus musculus (house mouse) ]

    Gene ID: 56464, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ctsfprovided by MGI
    Official Full Name
    cathepsin Fprovided by MGI
    Primary source
    MGI:MGI:1861434
    See related
    Ensembl:ENSMUSG00000083282 AllianceGenome:MGI:1861434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in adrenal gland and blood vessel. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 122.0), ovary adult (RPKM 42.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctsf in Genome Data Viewer
    Location:
    19 A; 19 4.12 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4905153..4910946)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4855165..4860918)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene copper chaperone for superoxide dismutase Neighboring gene STARR-positive B cell enhancer ABC_E9452 Neighboring gene coiled-coil domain containing 87 Neighboring gene STARR-seq mESC enhancer starr_45366 Neighboring gene actinin alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E3236 Neighboring gene zinc finger, DHHC domain containing 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. Santamaría I, et al. J Biol Chem, 1999 May 14. PMID 10318784
    2. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Tang CH, et al. Mol Cell Biol, 2006 Mar. PMID 16508006, Free PMC Article
    3. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Blednov YA, et al. Addict Biol, 2012 Jan. PMID 21309947, Free PMC Article
    4. Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene. Deussing J, et al. Gene, 2000 Jun 27. PMID 10876093
    5. Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expression. Tisljar K, et al. FEBS Lett, 1999 Oct 15. PMID 10526153

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This gene is known to be important for immune responses and may potentially regulate alcohol consumption.
      Title: Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies.
    2. cathepsin F inactivation causes a lysosomal storage defect and progressive neurological features in mice
      Title: Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin F
    NP_063914.1
    XP_030106864.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019861.2 → NP_063914.1  cathepsin F precursor

      See identical proteins and their annotated locations for NP_063914.1

      Status: VALIDATED

      Source sequence(s)
      AC141437
      Consensus CDS
      CCDS29440.1
      UniProtKB/Swiss-Prot
      Q9R013, Q9WUT4
      UniProtKB/TrEMBL
      Q9ES93
      Related
      ENSMUSP00000112481.2, ENSMUST00000119694.3
      Conserved Domains (2) summary
      smart00848
      Location:165 → 221
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:249 → 460
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4905153..4910946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251004.2 → XP_030106864.1  cathepsin F isoform X1

      UniProtKB/TrEMBL
      Q99KQ9
      Conserved Domains (2) summary
      smart00848
      Location:5 → 61
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:89 → 299
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R013.1 GenPept UniProtKB/Swiss-Prot:Q9R013

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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