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    Desi1 desumoylating isopeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 28075, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Desi1provided by MGI
    Official Full Name
    desumoylating isopeptidase 1provided by MGI
    Primary source
    MGI:MGI:106313
    See related
    Ensembl:ENSMUSG00000022472 AllianceGenome:MGI:106313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DeSI-1; Pppde2; Fam152b; D15Wsu75e
    Summary
    Enables SUMO-specific isopeptidase activity and identical protein binding activity. Involved in protein desumoylation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in extraembryonic component. Orthologous to human DESI1 (desumoylating isopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 105.5), thymus adult (RPKM 62.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 38.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81876724..81900364, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81992523..82016258, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S14 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11B Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 6 Neighboring gene STARR-positive B cell enhancer ABC_E7400 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene RIKEN cDNA 4930407I10 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DeSUMOylating isopeptidase: a second class of SUMO protease. Shin EJ, et al. EMBO Rep, 2012 Apr. PMID 22370726, Free PMC Article
    2. Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Kaput J, et al. Physiol Genomics, 2004 Aug 11. PMID 15306695
    3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A new deSUMOylase named DeSI-1 (DeSumoylating Isopeptidase 1), was identified.
      Title: DeSUMOylating isopeptidase: a second class of SUMO protease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables deSUMOylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein desumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification by small protein removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    desumoylating isopeptidase 1
    Names
    PPPDE peptidase domain containing 2
    PPPDE peptidase domain-containing protein 2
    S-depalmitoylase DESI1
    family with sequence similarity 152, member B
    palmitoyl protein thioesterase DESI1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356541.2 → NP_001343470.1  desumoylating isopeptidase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102176
      Conserved Domains (1) summary
      pfam05903
      Location:7 → 148
      Peptidase_C97; PPPDE putative peptidase domain

    2. NM_134095.4 → NP_598856.1  desumoylating isopeptidase 1 isoform 1

      See identical proteins and their annotated locations for NP_598856.1

      Status: VALIDATED

      Source sequence(s)
      AC102176
      Consensus CDS
      CCDS27681.1
      UniProtKB/Swiss-Prot
      Q3V2M9, Q9CQT7
      Related
      ENSMUSP00000121504.2, ENSMUST00000152227.8
      Conserved Domains (1) summary
      pfam05903
      Location:7 → 149
      Peptidase_C97; PPPDE putative peptidase domain

    RNA

    1. NR_177966.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102176
      Related
      ENSMUST00000146628.8

    2. NR_177967.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102176

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81876724..81900364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQT7.1 GenPept UniProtKB/Swiss-Prot:Q9CQT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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