Il27ra interleukin 27 receptor, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il27raprovided by MGI
Official Full Name: interleukin 27 receptor, alphaprovided by MGI
Primary source: MGI:MGI:1355318
See related: Ensembl:ENSMUSG00000005465 AllianceGenome:MGI:1355318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRL1; Tccr; Wsx1; WSX-1; IL-27R; zcytor1
Summary: Enables interleukin-27 receptor activity. Involved in negative regulation of T cell extravasation; negative regulation of T-helper 17 type immune response; and negative regulation of cytokine production. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; and regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL27RA (interleukin 27 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 26.4), thymus adult (RPKM 23.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 40.26 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84756915..84769250, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84030286..84042600, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-27/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation.
Title: IL-27/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation.
Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses.
Title: Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses.
IL-27 Ralpha(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.
Title: IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.
Loss of IL-27Ralpha Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.
Title: Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Title: Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjogren's Syndrome.
Title: Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome.
IL-27Ralpha: A Novel Molecular Imaging Marker for Allograft Rejection.
Title: IL-27Rα: A Novel Molecular Imaging Marker for Allograft Rejection.
IL-27 production was elevated during Clostridium difficile infection in humans and mice. Infected WSX-1-/- mice experienced increased weight loss, enhanced colonic histology damage, less Clostridium difficile clearance, and decreased survival compared to wild-type controls during Clostridium difficile infection.
Title: IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis.
this paper shows that the increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells
Title: The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells.
show that IL-27R signaling controls endothelial cells activation and myeloid cell recruitment at early and advanced stages of atherosclerosis. In the absence of IL-27R myeloid cells become hyperactivated, produce pro-inflammatory cytokines and act as more potent antigen presenting cells.
Title: IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

Il27ra (e-PCR), detects polymorphism
- UniSTS:532620

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-27 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-27 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell extravasation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of T-helper 17 type immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cellular extravasation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of interleukin-17 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T-helper 1 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-27 receptor subunit alpha

Names: IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; T cell cytokine receptor; T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1; cytokine receptor family, class 1 (WSXWS), member 1; type I T-cell cytokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425585.1 → NP_001412514.1 interleukin-27 receptor subunit alpha isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC156028
NM_016671.4 → NP_057880.2 interleukin-27 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_057880.2

Status: VALIDATED

Source sequence(s)

AC156028

Consensus CDS

CCDS22465.1

UniProtKB/Swiss-Prot

E9QNY4, O70394

UniProtKB/TrEMBL

Q3UZN3

Related

ENSMUSP00000005601.8, ENSMUST00000005601.9

Conserved Domains (1) summary

cd00063
Location:123 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

84756915..84769250 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154161.1 → XP_036010054.1 interleukin-27 receptor subunit alpha isoform X3

Conserved Domains (1) summary

cl21522
Location:93 → 172

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_011248437.3 → XP_011246739.1 interleukin-27 receptor subunit alpha isoform X2

Conserved Domains (2) summary

cd00063
Location:123 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:315 → 394

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036154162.1 → XP_036010055.1 interleukin-27 receptor subunit alpha isoform X4

Conserved Domains (1) summary

cd00063
Location:123 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...