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    Taf15 TATA-box binding protein associated factor 15 [ Mus musculus (house mouse) ]

    Gene ID: 70439, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Taf15provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 15provided by MGI
    Primary source
    MGI:MGI:1917689
    See related
    Ensembl:ENSMUSG00000020680 AllianceGenome:MGI:1917689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    68kDa; Taf2n; TAFII68; 2610111C21Rik
    Summary
    Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; hemolymphoid system gland; pancreas epithelium; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in chondrosarcoma and extraskeletal myxoid chondrosarcoma. Orthologous to human TAF15 (TATA-box binding protein associated factor 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 81.2), CNS E14 (RPKM 33.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf15 in Genome Data Viewer
    Location:
    11 C; 11 50.49 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83363897..83397569)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83473073..83506743)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene growth arrest-specific 2 like 2 Neighboring gene RIKEN cDNA 1700020L24 gene Neighboring gene matrix metallopeptidase 28 (epilysin) Neighboring gene STARR-positive B cell enhancer ABC_E1836 Neighboring gene STARR-seq mESC enhancer starr_30202 Neighboring gene STARR-seq mESC enhancer starr_30203 Neighboring gene predicted gene, 32650 Neighboring gene HEAT repeat containing 9 Neighboring gene predicted gene, 23247 Neighboring gene C-C motif chemokine ligand 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome. Ibrahim F, et al. Cell Rep, 2013 Feb 21. PMID 23416048, Free PMC Article
    2. miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15. Zhang L, et al. Biochem Biophys Res Commun, 2020 Aug 27. PMID 32736708
    3. Characterization of a new brain-specific isoform of the EWS oncoprotein. Melot T, et al. Eur J Biochem, 2001 Jun. PMID 11422378
    4. Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation. Svetoni F, et al. Hum Mol Genet, 2017 Jul 15. PMID 28453628
    5. The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. Gasperini L, et al. Mol Biol Cell, 2018 Dec 15. PMID 30354839, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAF15 exacerbates nonalcoholic steatohepatitis progression by regulating lipid metabolism and inflammation via FASN and p65 NF-kappaB.
      Title: TAF15 exacerbates nonalcoholic steatohepatitis progression by regulating lipid metabolism and inflammation via FASN and p65 NF-κB.
    2. miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15.
      Title: miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15.
    3. FUS and TAF15 exhibit similar global RNA interaction profiles in vivo, but affect a strikingly small subset of common genes. Unexpectedly, TAF15 influences a small fraction of amyotrophic lateral sclerosis events compared with TDP-43 and FUS in the mouse CNS.
      Title: Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
    4. TAF15 is required for a critical alternative splicing event of the zeta-1 subunit of the glutamate N-methyl-D-aspartate receptor (Grin1) that controls the activity and trafficking of NR1.
      Title: Identification of in vivo, conserved, TAF15 RNA binding sites reveals the impact of TAF15 on the neuronal transcriptome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TATA-binding protein-associated factor 2N
    Names
    TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA binding protein 56)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027427.3 → NP_081703.1  TATA-binding protein-associated factor 2N

      See identical proteins and their annotated locations for NP_081703.1

      Status: VALIDATED

      Source sequence(s)
      AK051568, AL596122
      Consensus CDS
      CCDS25168.1
      UniProtKB/TrEMBL
      Q8BQ46
      Related
      ENSMUSP00000021018.5, ENSMUST00000021018.11
      Conserved Domains (4) summary
      COG0724
      Location:221 → 317
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:230 → 315
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      sd00029
      Location:356 → 377
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:352 → 382
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83363897..83397569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246301.2 → XP_030102161.1  TATA-binding protein-associated factor 2N isoform X1

      Conserved Domains (5) summary
      PTZ00110
      Location:4 → 69
      PTZ00110; helicase; Provisional
      cd12535
      Location:197 → 282
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      TIGR01622
      Location:106 → 280
      SF-CC1; splicing factor, CC1-like family
      sd00029
      Location:323 → 344
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:320 → 349
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. XM_030246302.2 → XP_030102162.1  TATA-binding protein-associated factor 2N isoform X2

      Conserved Domains (5) summary
      PTZ00110
      Location:4 → 69
      PTZ00110; helicase; Provisional
      cd12535
      Location:178 → 263
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      sd00029
      Location:304 → 325
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:301 → 330
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam12273
      Location:102 → 153
      RCR; Chitin synthesis regulation, resistance to Congo red

    3. XM_030246304.1 → XP_030102164.1  TATA-binding protein-associated factor 2N isoform X3

      UniProtKB/TrEMBL
      F6QCI0
      Related
      ENSMUSP00000119836.2, ENSMUST00000133170.2
      Conserved Domains (3) summary
      cd12535
      Location:35 → 120
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      sd00029
      Location:161 → 182
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:158 → 187
      zf-RanBP; Zn-finger in Ran binding protein and others

    4. XM_030246305.2 → XP_030102165.1  TATA-binding protein-associated factor 2N isoform X4

      Conserved Domains (3) summary
      sd00025
      Location:89 → 110
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:85 → 115
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl17169
      Location:1 → 48
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_036156982.1 → XP_036012875.1  TATA-binding protein-associated factor 2N isoform X4

      Conserved Domains (3) summary
      sd00025
      Location:89 → 110
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:85 → 115
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl17169
      Location:1 → 48
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_036156984.1 → XP_036012877.1  TATA-binding protein-associated factor 2N isoform X4

      Conserved Domains (3) summary
      sd00025
      Location:89 → 110
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:85 → 115
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl17169
      Location:1 → 48
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_036156983.1 → XP_036012876.1  TATA-binding protein-associated factor 2N isoform X4

      Conserved Domains (3) summary
      sd00025
      Location:89 → 110
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:85 → 115
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl17169
      Location:1 → 48
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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