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    Krt84 keratin 84 [ Mus musculus (house mouse) ]

    Gene ID: 16680, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Krt84provided by MGI
    Official Full Name
    keratin 84provided by MGI
    Primary source
    MGI:MGI:96700
    See related
    Ensembl:ENSMUSG00000044294 AllianceGenome:MGI:96700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HRb-1; Krt2-3; Krt2-16
    Summary
    A structural constituent of skin epidermis. Involved in regulation of keratinocyte differentiation. Located in intermediate filament cytoskeleton. Is expressed in filiform papillae and tongue. Orthologous to human KRT84 (keratin 84). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F2; 15 56.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101433461..101441255, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101525026..101532820, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39797 Neighboring gene STARR-seq mESC enhancer starr_39798 Neighboring gene type II keratin Kb32P Neighboring gene predicted gene, 53914 Neighboring gene keratin 85 Neighboring gene STARR-seq mESC enhancer starr_39799 Neighboring gene keratin 82 Neighboring gene keratin 90

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture. McGowan K, et al. Subcell Biochem, 1998. PMID 9932493
    2. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation. Tobiasch E, et al. Differentiation, 1992 Aug. PMID 1385239
    3. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Jonker L, et al. Mech Dev, 2004 Nov. PMID 15454262
    4. Bcl11b/Ctip2 is required for development of lingual papillae in mice. Nishiguchi Y, et al. Dev Biol, 2016 Aug 1. PMID 27287879
    5. Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Poirier C, et al. Genetics, 2002 Oct. PMID 12399393, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
      Title: E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140837

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of skin epidermis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cuticular Hb4
    Names
    65 kDa type II keratin
    K84
    keratin complex 2, basic, gene 16
    keratin complex 2, gene 16
    type II hair keratin Hb4
    type-II keratin Kb24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008474.2 → NP_032500.2  keratin, type II cuticular Hb4

      See identical proteins and their annotated locations for NP_032500.2

      Status: VALIDATED

      Source sequence(s)
      AA738772, BC114971, BY779643, CF173770, CJ052880
      Consensus CDS
      CCDS27853.1
      UniProtKB/Swiss-Prot
      E9QMQ6, Q1RME6, Q61862, Q99M73
      Related
      ENSMUSP00000023720.8, ENSMUST00000023720.8
      Conserved Domains (4) summary
      pfam00038
      Location:173 → 483
      Filament; Intermediate filament protein
      pfam16208
      Location:16 → 169
      Keratin_2_head; Keratin type II head
      cl12013
      Location:217 → 372
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:390 → 452
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101433461..101441255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99M73.2 GenPept UniProtKB/Swiss-Prot:Q99M73

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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