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    Bora bora, aurora kinase A activator [ Mus musculus (house mouse) ]

    Gene ID: 77744, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Boraprovided by MGI
    Official Full Name
    bora, aurora kinase A activatorprovided by MGI
    Primary source
    MGI:MGI:1924994
    See related
    Ensembl:ENSMUSG00000022070 AllianceGenome:MGI:1924994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720463M24Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in activation of protein kinase activity; regulation of cell cycle process; and regulation of protein localization. Predicted to act upstream of or within cell division. Located in meiotic spindle. Is expressed in alimentary system; brain ventricular layer; cranium; renal cortex; and vibrissa. Orthologous to human BORA (BORA aurora kinase A activator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.9), limb E14.5 (RPKM 6.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 E2.2; 14 49.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99283880..99311976)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99046377..99074540)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41228 Neighboring gene predicted gene, 18148 Neighboring gene STARR-seq mESC enhancer starr_37423 Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene Kruppel-like transcription factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis. Zhai R, et al. Mol Reprod Dev, 2013 Jun. PMID 23610072
    2. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Hutterer A, et al. Dev Cell, 2006 Aug. PMID 16890155
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein aurora borealis
    Names
    aurora borealis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175265.6 → NP_780474.1  protein aurora borealis

      See identical proteins and their annotated locations for NP_780474.1

      Status: VALIDATED

      Source sequence(s)
      AC154843
      Consensus CDS
      CCDS27309.1
      UniProtKB/Swiss-Prot
      Q3TJH7, Q3UWZ8, Q80WQ5, Q8BS90, Q8C8E9
      Related
      ENSMUSP00000022656.7, ENSMUST00000022656.8
      Conserved Domains (1) summary
      pfam15280
      Location:8 → 204
      BORA_N; Protein aurora borealis N-terminus

    RNA

    1. NR_153765.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154843
      Related
      ENSMUST00000227744.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      99283880..99311976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519688.4 → XP_006519751.1  protein aurora borealis isoform X1

      Conserved Domains (1) summary
      pfam15280
      Location:27 → 75
      BORA_N; Protein aurora borealis N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BS90.1 GenPept UniProtKB/Swiss-Prot:Q8BS90

    Gene LinkOut

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