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    Actrt1 actin-related protein T1 [ Mus musculus (house mouse) ]

    Gene ID: 73360, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Actrt1provided by MGI
    Official Full Name
    actin-related protein T1provided by MGI
    Primary source
    MGI:MGI:1920610
    See related
    Ensembl:ENSMUSG00000046615 AllianceGenome:MGI:1920610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp-T1; 1700061J02Rik
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated and regulation of smoothened signaling pathway. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in nucleus. Orthologous to human ACTRT1 (actin related protein T1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    Location:
    X A4; X 24.54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (45417884..45419222)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (46329007..46330345)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52478 Neighboring gene RIKEN cDNA 4930515L19 gene Neighboring gene ribosomal protein L32 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47090 Neighboring gene ribosomal protein SA pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice. Zhang XZ, et al. Development, 2022 Jun 15. PMID 35616329
    2. Pathogenic Variants in ACTRT1 Cause Acephalic Spermatozoa Syndrome. Sha Y, et al. Front Cell Dev Biol, 2021. PMID 34422805, Free PMC Article
    3. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. Heid H, et al. Exp Cell Res, 2002 Oct 1. PMID 12243744
    4. Molecular evolution of the actin family. Goodson HV, et al. J Cell Sci, 2002 Jul 1. PMID 12077353
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
      Title: Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144637, MGC144638

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein T1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028514.3 → NP_082790.1  actin-related protein T1

      See identical proteins and their annotated locations for NP_082790.1

      Status: VALIDATED

      Source sequence(s)
      AK006855
      Consensus CDS
      CCDS30102.1
      UniProtKB/Swiss-Prot
      Q9D9J3
      Related
      ENSMUSP00000062570.3, ENSMUST00000059466.3
      Conserved Domains (2) summary
      smart00268
      Location:9 → 376
      ACTIN; Actin
      cl17037
      Location:8 → 376
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      45417884..45419222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9J3.1 GenPept UniProtKB/Swiss-Prot:Q9D9J3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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