Nbr1 NBR1, autophagy cargo receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nbr1provided by MGI
Official Full Name: NBR1, autophagy cargo receptorprovided by MGI
Primary source: MGI:MGI:108498
See related: Ensembl:ENSMUSG00000017119 AllianceGenome:MGI:108498
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0049
Summary: Enables mitogen-activated protein kinase binding activity. Involved in negative regulation of osteoblast differentiation; regulation of bone mineralization; and regulation of stress-activated MAPK cascade. Located in late endosome; mitochondrial intermembrane space; and phagophore assembly site. Colocalizes with autophagosome. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human NBR1 (NBR1 autophagy cargo receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 73.0), placenta adult (RPKM 24.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.36 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101442933..101472777)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101552107..101581951)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons.
Title: p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons.
Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.
Title: Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARgamma.
Title: NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.
Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.
Title: Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.
NBR1 is increased in adipose tissue macrophages in obese mice. The NBR1-MEKK3 complex is important in JNK activation in macrophages.
Title: A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.
NBR1 phosphorylation by GSK3 at Thr586 prevents the aggregation of ubiquitinated proteins and their selective autophagic degradation.
Title: Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
In a mouse model of Huntington disease, NBR1 protein levels were decreased in all brain regions analyzed early in the disease, whereas at late stages they accumulated in the striatum and hippocampus, but not in the cortex.
Title: Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease.
MURF2 expression parallels that of the autophagy-associated proteins LC3, p62/SQSTM1 and nbr1
Title: Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.
Results define Nbr1 as a negative regulator of ligand-mediated receptor tyrosine kinase degradation and reveal the interplay between its various regions for protein localization and function.
Title: Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.
NBR1 is a novel PB1 adapter in Th2 differentiation and asthma.
Title: NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nbr1 (e-PCR), detects polymorphism
- UniSTS:536423

D11Mit125 (e-PCR), detects polymorphism
- UniSTS:126315

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	TAS Traceable Author Statement more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: next to BRCA1 gene 1 protein

Names: membrane component chromosome 17 surface marker 2 homolog; neighbor of BRCA1 gene 1 protein; next to the Brca1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252220.1 → NP_001239149.1 next to BRCA1 gene 1 protein isoform 1

See identical proteins and their annotated locations for NP_001239149.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC052709, BC129868, CJ303949, CO433793

Consensus CDS

CCDS25475.1

UniProtKB/Swiss-Prot

P97432, Q9JIH9

UniProtKB/TrEMBL

A1L329, K3W4P1

Related

ENSMUSP00000099388.2, ENSMUST00000103099.8

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:938 → 976

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
NM_001252222.1 → NP_001239151.1 next to BRCA1 gene 1 protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK128992, BC052709, BC129867, CJ303949, CV558786

Consensus CDS

CCDS56811.1

UniProtKB/TrEMBL

A2A4N8, K3W4P1

Related

ENSMUSP00000102831.2, ENSMUST00000107213.8

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:901 → 939

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
NM_001252223.1 → NP_001239152.1 next to BRCA1 gene 1 protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in frame-shift and early translation termination, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK129043, BC052709, CJ303949, CV558786

Consensus CDS

CCDS56810.1

UniProtKB/TrEMBL

A2A4N5, Q6ZQK3

Related

ENSMUSP00000102826.2, ENSMUST00000107208.8

Conserved Domains (3) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
NM_008676.3 → NP_032702.1 next to BRCA1 gene 1 protein isoform 1

See identical proteins and their annotated locations for NP_032702.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).

Source sequence(s)

BC052709, BC129867, CJ303949, CV558786

Consensus CDS

CCDS25475.1

UniProtKB/Swiss-Prot

P97432, Q9JIH9

UniProtKB/TrEMBL

A1L329, K3W4P1

Related

ENSMUSP00000099387.3, ENSMUST00000103098.9

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:938 → 976

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RNA

NR_152788.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC052709, BP762124, CV558786

Related

ENSMUST00000123558.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

101442933..101472777

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532431.1 → XP_006532494.1 next to BRCA1 gene 1 protein isoform X1

See identical proteins and their annotated locations for XP_006532494.1

UniProtKB/TrEMBL

K3W4P1

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:944 → 982

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_006532430.1 → XP_006532493.1 next to BRCA1 gene 1 protein isoform X1

See identical proteins and their annotated locations for XP_006532493.1

UniProtKB/TrEMBL

K3W4P1

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:944 → 982

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_006532434.1 → XP_006532497.1 next to BRCA1 gene 1 protein isoform X5

UniProtKB/TrEMBL

Q6ZQK3

Conserved Domains (3) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_006532435.1 → XP_006532498.1 next to BRCA1 gene 1 protein isoform X6

UniProtKB/TrEMBL

Q05BC8

Conserved Domains (3) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_006532432.1 → XP_006532495.1 next to BRCA1 gene 1 protein isoform X2

UniProtKB/TrEMBL

K3W4P1

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:908 → 946

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_006532433.1 → XP_006532496.1 next to BRCA1 gene 1 protein isoform X3

UniProtKB/TrEMBL

K3W4P1

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:902 → 940

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_030245641.1 → XP_030101501.1 next to BRCA1 gene 1 protein isoform X7

UniProtKB/TrEMBL

Q6ZQK3

Conserved Domains (3) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_030245642.1 → XP_030101502.1 next to BRCA1 gene 1 protein isoform X8

UniProtKB/TrEMBL

Q05BC8

Conserved Domains (3) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
XM_030245639.1 → XP_030101499.1 next to BRCA1 gene 1 protein isoform X4

UniProtKB/TrEMBL

K3W4P1

Conserved Domains (4) summary

cd06396
Location:5 → 86

PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...

cd02340
Location:216 → 260

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd14319
Location:865 → 903

UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins

cd14947
Location:370 → 480

NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins