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    LACTB lactamase beta [ Homo sapiens (human) ]

    Gene ID: 114294, updated on 5-Mar-2024

    Summary

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    Official Symbol
    LACTBprovided by HGNC
    Official Full Name
    lactamase betaprovided by HGNC
    Primary source
    HGNC:HGNC:16468
    See related
    Ensembl:ENSG00000103642 MIM:608440; AllianceGenome:HGNC:16468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G24; MRPL56
    Summary
    This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.0), adrenal (RPKM 7.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63121861..63142061)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (60926721..60946916)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63414060..63434260)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6507 Neighboring gene TPM1 antisense RNA Neighboring gene tropomyosin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63370949-63371626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63371627-63372302 Neighboring gene VISTA enhancer hs2160 Neighboring gene Sharpr-MPRA regulatory region 14461 Neighboring gene uncharacterized LOC107984798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6510 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:63448416-63449615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6511 Neighboring gene ribosomal protein S27 like Neighboring gene uncharacterized LOC101928972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6512

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding. Bennett JA, et al. PLoS Biol, 2022 Dec. PMID 36534696, Free PMC Article
    2. LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. Gonzalez-Morena JM, et al. Apoptosis, 2023 Feb. PMID 36282364, Free PMC Article
    3. LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway. Hu Y, et al. Biochem Biophys Res Commun, 2022 Nov 12. PMID 36088805
    4. Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. Zhang M, et al. Structure, 2022 May 5. PMID 35247327
    5. [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines]. Liu ZY, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2021 Aug. PMID 34362477

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
      Title: OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
    2. PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
      Title: PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
    3. LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.
      Title: LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.
    4. The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
      Title: The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
    5. Clinical Significance of beta-Lactamase Expression in Colorectal Cancer.
      Title: Clinical Significance of β-Lactamase Expression in Colorectal Cancer.
    6. LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
      Title: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
    7. LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway.
      Title: LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway.
    8. Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
      Title: Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
    9. LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.
      Title: LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.
    10. [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines].
      Title: [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines].
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Human metabolic individuality in biomedical and pharmaceutical research.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14902

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine beta-lactamase-like protein LACTB, mitochondrial
    Names
    mitochondrial 39S ribosomal protein L56
    serine beta-lactamase-like protein, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050565.1 RefSeqGene

      Range
      5062..25262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288585.2 → NP_001275514.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 3' coding region and 3' UTR, compared to variant 1, one of which results in a frameshift. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AA186367, AC087612, AK027808, BC037198
      UniProtKB/Swiss-Prot
      P83111
      Conserved Domains (1) summary
      pfam00144
      Location:112 → 223
      Beta-lactamase; Beta-lactamase

    2. NM_032857.5 → NP_116246.2  serine beta-lactamase-like protein LACTB, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_116246.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC067288
      Consensus CDS
      CCDS10182.1
      UniProtKB/Swiss-Prot
      P83096, P83111
      Related
      ENSP00000261893.4, ENST00000261893.9
      Conserved Domains (1) summary
      pfam00144
      Location:112 → 524
      Beta-lactamase; Beta-lactamase

    3. NM_171846.4 → NP_741982.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform b precursor

      See identical proteins and their annotated locations for NP_741982.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 3' coding exon and its 3' terminal exon extends past a splice site that it used in variant 1, resulting in a distinct 3' UTR. The encoded isoform (b) has a shorter C-terminus than isoform a.
      Source sequence(s)
      AA186367, AC087612, AK027808, AY358709, BC037198
      Consensus CDS
      CCDS45275.1
      UniProtKB/Swiss-Prot
      P83111
      Related
      ENSP00000392956.2, ENST00000413507.3
      Conserved Domains (1) summary
      pfam00144
      Location:112 → 356
      Beta-lactamase; Beta-lactamase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      63121861..63142061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432128.1 → XP_047288084.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      60926721..60946916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377234.1 → XP_054233209.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83111.2 GenPept UniProtKB/Swiss-Prot:P83111

    Gene LinkOut

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