IFIT2 interferon induced protein with tetratricopeptide repeats 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFIT2provided by HGNC
Official Full Name: interferon induced protein with tetratricopeptide repeats 2provided by HGNC
Primary source: HGNC:HGNC:5409
See related: Ensembl:ENSG00000119922 MIM:147040; AllianceGenome:HGNC:5409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; ISG-54; GARG-39; IFI-54K; ISG-54K; ISG-54 K
Summary: Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bone marrow (RPKM 19.8), spleen (RPKM 15.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.31

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (89302046..89309271)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (90185914..90193139)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (91061803..91069028)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-199a-5P promotes osteogenic differentiation of human stem cells from apical papilla via targeting IFIT2 in apical periodontitis.
Title: MiR-199a-5P promotes osteogenic differentiation of human stem cells from apical papilla via targeting IFIT2 in apical periodontitis.
Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.
Title: Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.
PML-II regulates ERK and AKT signal activation and IFNalpha-induced cell death.
Title: PML-II regulates ERK and AKT signal activation and IFNα-induced cell death.
Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy.
Title: Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy.
Super-enhancer-associated long noncoding RNA RP11-569A11.1 inhibited cell progression and metastasis by regulating IFIT2 in colorectal cancer.
Title: Super-enhancer-associated long noncoding RNA RP11-569A11.1 inhibited cell progression and metastasis by regulating IFIT2 in colorectal cancer.
Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs.
Title: Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs.
Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCRABL/AKT/mTOR pathway.
Title: Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR‑ABL/AKT/mTOR pathway.
IFIT2 and IFIT3 stabilize IFIT1 expression.
Title: IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
Studied effect of baicalein on gene expression in human breast cancer cell line and found baicalein reduced stem cell-like properties of the cells and induced apoptosis through up-regulation of IFIT2.
Title: Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-231 Human Breast Cancer Cells through Up-Regulation of IFIT2.
These studies indicated PLZF inhibited the proliferation and metastasis via regulation of IFIT2.
Title: PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of interferon-induced protein with tetratricopeptide repeats 2 (IFIT2; IFI54) in immature dendritic cells and monocyte-derived macrophages	PubMed
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells	PubMed
	vpr	HIV-1 Vpr upregulates the gene expression of IFIT1 in human monocyte-derived dendritic cells	PubMed
Vpu	vpu	The expression of IFIT2 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46192 (e-PCR)
- UniSTS:47160

RH48237 (e-PCR)
- UniSTS:44350

PMC299790P1 (e-PCR)
- UniSTS:272461

GDB:193863 (e-PCR)
- UniSTS:155771

RH69073 (e-PCR)
- UniSTS:35991

SGC38130 (e-PCR)
- UniSTS:6831

G59773 (e-PCR)
- UniSTS:136926

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic mitochondrial changes	TAS Traceable Author Statement more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 2

Names: Interferon, alpha-inducible protein (MW 54kD); interferon-induced 54 kDa protein; interferon-induced protein 54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.