Adk adenosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adkprovided by MGI
Official Full Name: adenosine kinaseprovided by MGI
Primary source: MGI:MGI:87930
See related: Ensembl:ENSMUSG00000039197 AllianceGenome:MGI:87930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ak; 2310026J05Rik; 5033405D03Rik
Summary: Enables adenosine kinase activity and deoxyadenosine kinase activity. Involved in AMP salvage; GMP salvage; and dAMP salvage. Acts upstream of or within dATP biosynthetic process and purine ribonucleoside salvage. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.58 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (21102622..21498637)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (21052574..21448569)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental and foliation changes due to dysregulation of adenosine kinase in the cerebellum.
Title: Developmental and foliation changes due to dysregulation of adenosine kinase in the cerebellum.
Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation.
Title: Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation.
Deletion of pancreatic beta-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia.
Title: Deletion of pancreatic β-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia.
Data sugggest adenosine kinase (ADK) is a potential target for the prevention and treatment of metabolic disorders associated with insulin resistance.
Title: Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.
Augmentation of intracellular adenosine levels through ADK knockout in myeloid cells protects ApoE(-/-) mice against atherosclerosis by reducing foam cell formation via the epigenetic regulation of cholesterol trafficking.
Title: Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE(-/-) (Apolipoprotein E Deficient) Mice.
results demonstrate a key developmental role of ADK in mediating behaviors in adulthood related to neuropsychiatric disease and support the greater prevalence of these disorders among males.
Title: Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior.
These results suggest that mice with ADK deficiency have reduced bone formation due to increased osteoclastogenesis and bone resorption.
Title: Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice.
Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in mice.
Title: Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.
ADK expression negatively regulates the adaptive beta-cell response to high-fat diet challenge.
Title: Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance.
Our data show that neurological phenotypes in ADK-deficient patients are intrinsic to ADK deficiency in the brain and that blocking A2AR activity therapeutically can attenuate neurological symptoms in ADK deficiency.
Title: Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D14Mit251 (e-PCR), detects polymorphism
- UniSTS:127362

AI987814 (e-PCR)
- UniSTS:180620

Adk (e-PCR), detects polymorphism
- UniSTS:141036

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables adenosine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxyadenosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within AMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in AMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in adenosine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dAMP salvage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine ribonucleoside salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine kinase

Names: adenosine 5'-phosphotransferase

NP_001229970.1

EC 2.7.1.20

NP_598840.1

EC 2.7.1.20

XP_006518503.1

EC 2.7.1.20

XP_006518504.1

EC 2.7.1.20

XP_030103470.1

EC 2.7.1.20

XP_030103471.1

EC 2.7.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243041.1 → NP_001229970.1 adenosine kinase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AI194759, AK151863

Consensus CDS

CCDS88589.1

UniProtKB/Swiss-Prot

P55264

Related

ENSMUSP00000153089.2, ENSMUST00000224069.2

Conserved Domains (1) summary

cl00192
Location:12 → 344

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
NM_134079.4 → NP_598840.1 adenosine kinase isoform 1

See identical proteins and their annotated locations for NP_598840.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC163681, AI194759, AK032871, AK160264, AY540996

Consensus CDS

CCDS26862.1

UniProtKB/Swiss-Prot

P55264, Q6JAM3, Q91VJ3

Related

ENSMUSP00000047665.10, ENSMUST00000045376.11

Conserved Domains (1) summary

cl00192
Location:28 → 360

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

21102622..21498637

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518441.4 → XP_006518504.1 adenosine kinase isoform X3

UniProtKB/TrEMBL

Q8BMC5

Conserved Domains (1) summary

cl00192
Location:28 → 241

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_006518440.5 → XP_006518503.1 adenosine kinase isoform X1

UniProtKB/TrEMBL

Q8BMC5

Conserved Domains (1) summary

cl00192
Location:28 → 241

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_030247610.2 → XP_030103470.1 adenosine kinase isoform X2

UniProtKB/TrEMBL

Q8BMC5

Conserved Domains (1) summary

cl00192
Location:12 → 225

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
XM_030247611.1 → XP_030103471.1 adenosine kinase isoform X4

UniProtKB/TrEMBL

Q8BMC5

Conserved Domains (1) summary

cl00192
Location:12 → 225

ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...