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    Apip APAF1 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 56369, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Apipprovided by MGI
    Official Full Name
    APAF1 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1926788
    See related
    Ensembl:ENSMUSG00000010911 AllianceGenome:MGI:1926788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APIP2; CGI-29; Mmrp19
    Summary
    Predicted to enable identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Involved in regulation of ERK1 and ERK2 cascade. Acts upstream of or within negative regulation of apoptotic process. Predicted to be active in cytoplasm. Orthologous to human APIP (APAF1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 17.9), limb E14.5 (RPKM 12.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E2; 2 54.29 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102904020..102922994)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103073675..103092649)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9522 Neighboring gene STARR-positive B cell enhancer ABC_E2632 Neighboring gene predicted gene, 34483 Neighboring gene STARR-positive B cell enhancer ABC_E5951 Neighboring gene STARR-positive B cell enhancer ABC_E5952 Neighboring gene pyruvate dehydrogenase complex, component X Neighboring gene STARR-positive B cell enhancer mm9_chr2:102913613-102913914 Neighboring gene STARR-seq mESC enhancer starr_05263 Neighboring gene STARR-seq mESC enhancer starr_05264 Neighboring gene STARR-seq mESC enhancer starr_05265 Neighboring gene predicted gene 13869 Neighboring gene ets homologous factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Suppression of hypoxic cell death by APIP-induced sustained activation of AKT and ERK1/2. Cho DH, et al. Oncogene, 2007 Apr 26. PMID 17086211
    2. Cardioprotective role of APIP in myocardial infarction through ADORA2B. Lim B, et al. Cell Death Dis, 2019 Jul 1. PMID 31263105, Free PMC Article
    3. APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. Hong SH, et al. Oncotarget, 2016 Apr 19. PMID 26942872, Free PMC Article
    4. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein. Cho DH, et al. J Biol Chem, 2004 Sep 17. PMID 15262985
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylthioribulose 1-phosphate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylthioribulose 1-phosphate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyroptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methylthioribulose-1-phosphate dehydratase
    Names
    MTRu-1-P dehydratase
    monocyte macrophage 19
    monocyte/macrophage protein 19
    probable methylthioribulose-1-phosphate dehydratase
    NP_001342402.1
    NP_001342403.1
    NP_062709.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355473.1 → NP_001342402.1  methylthioribulose-1-phosphate dehydratase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL954375
      Conserved Domains (1) summary
      TIGR03328
      Location:27 → 212
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase

    2. NM_001355474.1 → NP_001342403.1  methylthioribulose-1-phosphate dehydratase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL954375
      Related
      ENSMUST00000124540.8
      Conserved Domains (1) summary
      cl00214
      Location:1 → 154
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    3. NM_019735.4 → NP_062709.3  methylthioribulose-1-phosphate dehydratase isoform 1

      See identical proteins and their annotated locations for NP_062709.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK077705, AK145450, AV060627
      Consensus CDS
      CCDS16474.1
      UniProtKB/Swiss-Prot
      Q8BP46, Q9WVQ5
      Related
      ENSMUSP00000011055.7, ENSMUST00000011055.7
      Conserved Domains (1) summary
      TIGR03328
      Location:27 → 225
      salvage_mtnB; methylthioribulose-1-phosphate dehydratase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      102904020..102922994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVQ5.1 GenPept UniProtKB/Swiss-Prot:Q9WVQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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