LINC01088 long intergenic non-protein coding RNA 1088 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINC01088provided by HGNC
Official Full Name: long intergenic non-protein coding RNA 1088provided by HGNC
Primary source: HGNC:HGNC:49148
See related: Ensembl:ENSG00000249307 AllianceGenome:HGNC:49148
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in brain (RPKM 3.9), prostate (RPKM 2.6) and 11 other tissues See more
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Genomic context

Location:: 4q21.21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (78971748..79308799)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (82307361..82644579)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (79892902..80229953)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis.
Title: Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis.
Upregulated LINC01088 facilitates malignant phenotypes and immune escape of colorectal cancer by regulating microRNAs/G3BP1/PD-L1 axis.
Title: Upregulated LINC01088 facilitates malignant phenotypes and immune escape of colorectal cancer by regulating microRNAs/G3BP1/PD-L1 axis.
Low LINC01088 expression was associated with the progression of epithelial ovarian cancer.
Title: The down-regulation of long non-coding RNA LINC01088 is associated with the poor prognosis of epithelial ovarian cancer patients.
LINC01088 might function as a tumor suppressor, inhibiting the tumorigenesis of ovarian epithelial cells through LINC01088/ miR-24-1-5p/ PAK4 axis
Title: LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

AFM211yf6 (e-PCR), detects polymorphism
- UniSTS:92673

G16768 (e-PCR)
- UniSTS:23837

D4S1289 (e-PCR)
- UniSTS:70689

G16735 (e-PCR)
- UniSTS:15151

D4S2963 (e-PCR)
- UniSTS:79669

SHGC-67721 (e-PCR)
- UniSTS:58466

SHGC-53329 (e-PCR)
- UniSTS:60785

G33896 (e-PCR)
- UniSTS:10098

SHGC-24440 (e-PCR)
- UniSTS:10099

SHGC-37478 (e-PCR)
- UniSTS:8581

G59273 (e-PCR)
- UniSTS:136588

STS-N40474 (e-PCR)
- UniSTS:62914

SHGC-60108 (e-PCR)
- UniSTS:16323

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.