Cd36 CD36 molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd36provided by MGI
Official Full Name: CD36 moleculeprovided by MGI
Primary source: MGI:MGI:107899
See related: Ensembl:ENSMUSG00000002944 AllianceGenome:MGI:107899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FAT; GPIV; Scarb3
Summary: Enables lipoprotein particle binding activity; lipoteichoic acid immune receptor activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of gene expression; and regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including phagocytosis; positive regulation of cytokine production; and response to bacterium. Located in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including Meckel's cartilage; axial skeleton; bone; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 144.0), heart adult (RPKM 110.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 8.11 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (17986680..18093828, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (17781690..17888959, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function.
Title: CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function.
RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression.
Title: RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression.
Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC.
Title: Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC.
Early-life stress perturbs the epigenetics of Cd36 concurrent with adult onset of NAFLD in mice.
Title: Early-life stress perturbs the epigenetics of Cd36 concurrent with adult onset of NAFLD in mice.
Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis.
Title: Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis.
CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway.
Title: CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway.
The effects of intermittent hypoxia on hepatic expression of fatty acid translocase CD36 in lean and diet-induced obese mice.
Title: The effects of intermittent hypoxia on hepatic expression of fatty acid translocase CD36 in lean and diet-induced obese mice.
Cluster-determinant 36 (CD36) mediates intestinal absorption of dietary astaxanthin and affects its secretion.
Title: Cluster-determinant 36 (CD36) mediates intestinal absorption of dietary astaxanthin and affects its secretion.
LncRNA AK142643 promotes hepatic lipid accumulation by upregulating CD36 via interacting with IGF2BP2.
Title: LncRNA AK142643 promotes hepatic lipid accumulation by upregulating CD36 via interacting with IGF2BP2.
Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels.
Title: Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels.

Submit: New GeneRIF Correction See all GeneRIFs (327)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC164515P2 (e-PCR)
- UniSTS:271489

Cd36 (e-PCR), detects polymorphism
- UniSTS:141277

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid immune receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables oleate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oleic acid binding	ISO Inferred from Sequence Orthology more info
enables oxidised low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info
enables short-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thrombospondin receptor activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid fibril formation	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance by cellular catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to bacterial lipopeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroperoxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipoteichoic acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipoteichoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal cholesterol absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in oxidised low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood microparticle formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage derived foam cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to fatty acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to linoleic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed
involved_in short-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
is_active_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet glycoprotein 4

Names: CD36 antigen; GPIIIB; PAS IV; PAS-4; fatty acid translocase; glycoprotein IIIb; platelet glycoprotein IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159555.2 → NP_001153027.1 platelet glycoprotein 4

See identical proteins and their annotated locations for NP_001153027.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC154124

Consensus CDS

CCDS19100.1

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3TA14, Q3UAI3, Q3UC79, Q8C6Z4

Related

ENSMUSP00000143061.2, ENSMUST00000197890.5

Conserved Domains (1) summary

pfam01130
Location:16 → 463

CD36; CD36 family
NM_001159556.2 → NP_001153028.1 platelet glycoprotein 4

See identical proteins and their annotated locations for NP_001153028.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC154124

Consensus CDS

CCDS19100.1

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3TA14, Q3UAI3, Q3UC79, Q8C6Z4

Related

ENSMUSP00000133008.2, ENSMUST00000170051.8

Conserved Domains (1) summary

pfam01130
Location:16 → 463

CD36; CD36 family
NM_001159557.2 → NP_001153029.1 platelet glycoprotein 4

See identical proteins and their annotated locations for NP_001153029.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC154124

Consensus CDS

CCDS19100.1

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3TA14, Q3UAI3, Q3UC79, Q8C6Z4

Related

ENSMUSP00000126300.2, ENSMUST00000165232.8

Conserved Domains (1) summary

pfam01130
Location:16 → 463

CD36; CD36 family
NM_001159558.2 → NP_001153030.1 platelet glycoprotein 4

See identical proteins and their annotated locations for NP_001153030.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AC154124

Consensus CDS

CCDS19100.1

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3TA14, Q3UAI3, Q3UC79, Q8C6Z4

Related

ENSMUSP00000131832.2, ENSMUST00000169095.6

Conserved Domains (1) summary

pfam01130
Location:16 → 463

CD36; CD36 family
NM_001421118.1 → NP_001408047.1 platelet glycoprotein 4

Status: VALIDATED

Source sequence(s)

AC154124

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3UAI3
NM_001421119.1 → NP_001408048.1 platelet glycoprotein 4

Status: VALIDATED

Source sequence(s)

AC154124

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3UAI3
NM_001421120.1 → NP_001408049.1 platelet glycoprotein 4

Status: VALIDATED

Source sequence(s)

AC154124

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3UAI3
NM_001421121.1 → NP_001408050.1 platelet glycoprotein 4

Status: VALIDATED

Source sequence(s)

AC154124

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3UAI3
NM_007643.5 → NP_031669.3 platelet glycoprotein 4

See identical proteins and their annotated locations for NP_031669.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AC154124

Consensus CDS

CCDS19100.1

UniProtKB/Swiss-Prot

Q08857

UniProtKB/TrEMBL

Q3TA14, Q3UAI3, Q3UC79, Q8C6Z4

Related

ENSMUSP00000080974.7, ENSMUST00000082367.13

Conserved Domains (1) summary

pfam01130
Location:16 → 463

CD36; CD36 family