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    Bdh2 3-hydroxybutyrate dehydrogenase, type 2 [ Mus musculus (house mouse) ]

    Gene ID: 69772, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bdh2provided by MGI
    Official Full Name
    3-hydroxybutyrate dehydrogenase, type 2provided by MGI
    Primary source
    MGI:MGI:1917022
    See related
    Ensembl:ENSMUSG00000028167 AllianceGenome:MGI:1917022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dhrs6; 1810026B04Rik
    Summary
    Enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Involved in iron ion homeostasis and siderophore biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cranium; ear; genitourinary system; and respiratory system. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 79.3), liver adult (RPKM 4.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Bdh2 in Genome Data Viewer
    Location:
    3 G3; 3 62.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (134986982..135010187)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135281221..135304426)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09052 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11219 Neighboring gene STARR-positive B cell enhancer ABC_E8965 Neighboring gene centromere protein E Neighboring gene predicted gene, 46826 Neighboring gene STARR-seq mESC enhancer starr_09056 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene STARR-seq mESC enhancer starr_09057 Neighboring gene STARR-seq mESC enhancer starr_09058 Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection. Liu Z, et al. J Exp Med, 2014 Jun 2. PMID 24863067, Free PMC Article
    2. Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice. Liu Z, et al. Mol Cell Biol, 2014 Jul. PMID 24777603, Free PMC Article
    3. 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation. Yang B, et al. Bioengineered, 2022 Feb. PMID 35001849, Free PMC Article
    4. 3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron. Liu Z, et al. FEBS J, 2014 May. PMID 24673886
    5. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Devireddy LR, et al. Cell, 2010 Jun 11. PMID 20550936, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.
      Title: 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic lupus erythematosus progression in a mouse model by promoting CD40 ligand demethylation.
    2. 3-hydroxybutyrate dehydrogenase-2 catalyzes a rate-limiting step in the biogenesis of the mammalian siderophore.
      Title: 3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron.
    3. these findings demonstrate a key role for BDH2 in erythropoiesis.
      Title: Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxybutyrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxybutyrate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-oxoproline reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect intracellular sequestering of iron ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siderophore biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 6
    Names
    (R)-beta-hydroxybutyrate dehydrogenase
    4-oxo-L-proline reductase
    R-beta-hydroxybutyrate dehydrogenase
    dehydrogenase/reductase (SDR family) member 6
    oxidoreductase UCPA
    short chain dehydrogenase/reductase family 15C member 1
    NP_001165526.1
    NP_081484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172055.1 → NP_001165526.1  dehydrogenase/reductase SDR family member 6 isoform 1

      See identical proteins and their annotated locations for NP_001165526.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC104874
      Consensus CDS
      CCDS51073.1
      UniProtKB/TrEMBL
      G3UWD3
      Related
      ENSMUSP00000112683.3, ENSMUST00000120397.8
      Conserved Domains (2) summary
      cd05368
      Location:15 → 255
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:12 → 254
      PRK06138; short chain dehydrogenase; Provisional

    2. NM_027208.2 → NP_081484.1  dehydrogenase/reductase SDR family member 6 isoform 2

      See identical proteins and their annotated locations for NP_081484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC104874
      Consensus CDS
      CCDS17853.1
      UniProtKB/Swiss-Prot
      Q8JZV9
      Related
      ENSMUSP00000029817.8, ENSMUST00000029817.11
      Conserved Domains (2) summary
      cd05368
      Location:5 → 245
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:2 → 244
      PRK06138; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      134986982..135010187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZV9.1 GenPept UniProtKB/Swiss-Prot:Q8JZV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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