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    Syngr2 synaptogyrin 2 [ Mus musculus (house mouse) ]

    Gene ID: 20973, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Syngr2provided by MGI
    Official Full Name
    synaptogyrin 2provided by MGI
    Primary source
    MGI:MGI:1328324
    See related
    Ensembl:ENSMUSG00000048277 AllianceGenome:MGI:1328324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clast2; cellugyrin
    Summary
    Predicted to be involved in regulated exocytosis and synaptic vesicle membrane organization. Predicted to act upstream of or within protein targeting. Located in synaptic vesicle. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SYNGR2 (synaptogyrin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 184.2), stomach adult (RPKM 158.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syngr2 in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117700459..117705112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117809646..117814286)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9147 Neighboring gene predicted gene 11723 Neighboring gene transmembrane channel-like gene family 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117655547-117655805 Neighboring gene RIKEN cDNA 6030468B19 gene Neighboring gene STARR-positive B cell enhancer ABC_E5305 Neighboring gene STARR-positive B cell enhancer ABC_E5306 Neighboring gene thymidine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E11501 Neighboring gene STARR-positive B cell enhancer ABC_E4020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693509-117693710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693767-117693876 Neighboring gene arylformamidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117710178-117710379 Neighboring gene baculoviral IAP repeat-containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles. Li LV, et al. Biochem J, 2009 Apr 1. PMID 19076072, Free PMC Article
    2. Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells. Belfort GM, et al. J Biol Chem, 2003 Nov 28. PMID 12928441
    3. Characterization of the human synaptogyrin gene family. Kedra D, et al. Hum Genet, 1998 Aug. PMID 9760194
    4. TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. Beaton N, et al. Mol Metab, 2015 Nov. PMID 26629404, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment
      Title: Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptogyrin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009304.2 → NP_033330.1  synaptogyrin-2

      See identical proteins and their annotated locations for NP_033330.1

      Status: VALIDATED

      Source sequence(s)
      AK089424, AK150234, BB368123, BY146297
      Consensus CDS
      CCDS25691.1
      UniProtKB/Swiss-Prot
      O55101, Q3TCK2, Q8C225, Q99K83
      UniProtKB/TrEMBL
      B0QZP8
      Related
      ENSMUSP00000026649.8, ENSMUST00000026649.14
      Conserved Domains (1) summary
      pfam01284
      Location:20 → 165
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117700459..117705112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245751.2 → XP_030101611.1  synaptogyrin-2 isoform X1

      UniProtKB/TrEMBL
      H3BJ78
      Related
      ENSMUSP00000134879.2, ENSMUST00000175737.2
      Conserved Domains (1) summary
      pfam01284
      Location:20 → 117
      MARVEL; Membrane-associating domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55101.1 GenPept UniProtKB/Swiss-Prot:O55101

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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