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    Phpt1 phosphohistidine phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 75454, updated on 5-Mar-2024

    Summary

    Official Symbol
    Phpt1provided by MGI
    Official Full Name
    phosphohistidine phosphatase 1provided by MGI
    Primary source
    MGI:MGI:1922704
    See related
    Ensembl:ENSMUSG00000036504 AllianceGenome:MGI:1922704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PHP; Php14; 1700008C22Rik
    Summary
    Predicted to enable calcium channel inhibitor activity; protein histidine phosphatase activity; and transmembrane transporter binding activity. Involved in positive regulation of cell motility. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 79.5), CNS E14 (RPKM 73.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2 A3; 2 17.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25463442..25465528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25573430..25575514, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endothelial differentiation-related factor 1 Neighboring gene MAM domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E1582 Neighboring gene apical junction component 1 Neighboring gene RAB, member RAS oncogene family-like 6 Neighboring gene coiled-coil domain containing 183 Neighboring gene ficolin A, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein histidine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein histidine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in leading edge of lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    14 kDa phosphohistidine phosphatase
    Names
    protein histidine phosphatase
    NP_001405736.1
    NP_083569.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418807.1NP_001405736.1  14 kDa phosphohistidine phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL732590
    2. NM_029293.2NP_083569.1  14 kDa phosphohistidine phosphatase isoform 2

      See identical proteins and their annotated locations for NP_083569.1

      Status: VALIDATED

      Source sequence(s)
      AL732590
      Consensus CDS
      CCDS15781.1
      UniProtKB/Swiss-Prot
      Q9DAK9
      Related
      ENSMUSP00000037417.7, ENSMUST00000039156.7
      Conserved Domains (1) summary
      pfam05005
      Location:8113
      Ocnus; Janus/Ocnus family (Ocnus)

    RNA

    1. NR_184822.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732590
    2. NR_184823.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732590
    3. NR_184824.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732590
    4. NR_184825.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732590
    5. NR_184826.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732590
    6. NR_184827.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732590
      Related
      ENSMUST00000147096.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25463442..25465528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)