GSTO1 glutathione S-transferase omega 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSTO1provided by HGNC
Official Full Name: glutathione S-transferase omega 1provided by HGNC
Primary source: HGNC:HGNC:13312
See related: Ensembl:ENSG00000148834 MIM:605482; AllianceGenome:HGNC:13312
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
Summary: The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression: Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q25.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (104254173..104267455)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (105142310..105155591)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (106013931..106027213)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSTO1 confers drug resistance in HCT116 colon cancer cells through an interaction with TNFalphaIP3/A20.
Title: GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20.
The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
Title: The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.
Title: Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.
Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
Title: Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Title: Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.
Title: Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.
Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
Title: Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
Glutathione Stransferase omega 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of nonsmall cell lung cancer cells, via the JAK/STAT3 signaling pathway.
Title: Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway.
Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor.
Title: Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor.
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
Title: Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-37586 (e-PCR)
- UniSTS:8975

G34966 (e-PCR)
- UniSTS:117676

RH67640 (e-PCR)
- UniSTS:84178

RH71268 (e-PCR)
- UniSTS:18906

RH79001 (e-PCR)
- UniSTS:18907

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione dehydrogenase (ascorbate) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables methylarsonate reductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-ascorbic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ascorbic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	IC Inferred by Curator more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC Inferred by Curator more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase omega-1

Names: MMA(V) reductase; S-(Phenacyl)glutathione reductase; epididymis secretory protein Li 21; glutathione S-transferase omega 1-1; glutathione-S-transferase like; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase

NP_001177931.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

NP_001177932.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

NP_004823.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023362.1 RefSeqGene

Range

5699..18262

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001191002.2 → NP_001177931.1 glutathione S-transferase omega-1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CA431506, CN283947, DT220068

Consensus CDS

CCDS53572.1

UniProtKB/TrEMBL

Q5TA01

Related

ENSP00000358724.4, ENST00000369710.8

Conserved Domains (3) summary

cd03184
Location:84 → 196

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

COG0625
Location:26 → 177

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03055
Location:5 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
NM_001191003.2 → NP_001177932.1 glutathione S-transferase omega-1 isoform 3

See identical proteins and their annotated locations for NP_001177932.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL139341, CA431506, CF130513, DB501888

Consensus CDS

CCDS53573.1

UniProtKB/TrEMBL

Q5TA02

Related

ENSP00000441488.1, ENST00000539281.5

Conserved Domains (3) summary

PRK10542
Location:12 → 192

PRK10542; glutathionine S-transferase; Provisional

cd03184
Location:80 → 201

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cl00388
Location:1 → 66

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_004832.3 → NP_004823.1 glutathione S-transferase omega-1 isoform 1

See identical proteins and their annotated locations for NP_004823.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BX537431

Consensus CDS

CCDS7555.1

UniProtKB/Swiss-Prot

D3DRA3, F5H7H0, P78417, Q5TA03, Q7Z3T2

UniProtKB/TrEMBL

B2R983, V9HWG9

Related

ENSP00000358727.5, ENST00000369713.10

Conserved Domains (2) summary

cd03184
Location:108 → 229

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cd03055
Location:5 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...