Tnmd tenomodulin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnmdprovided by MGI
Official Full Name: tenomodulinprovided by MGI
Primary source: MGI:MGI:1929885
See related: Ensembl:ENSMUSG00000031250 AllianceGenome:MGI:1929885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TeM; ChM1L; Bricd4; 1110017I01Rik
Summary: Acts upstream of or within endothelial cell morphogenesis; negative regulation of angiogenesis; and negative regulation of endothelial cell proliferation. Predicted to be located in membrane and nucleus. Predicted to be integral component of membrane. Is expressed in several structures, including brain; limb; sensory organ; skeletal system; and spinal cord. Orthologous to human TNMD (tenomodulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 26.1) and CNS E14 (RPKM 2.6) See more
Orthologs: human all
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Genomic context

Location:: X E3; X 55.47 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (132751757..132766326)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (133851008..133865577)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration.
Title: Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration.
Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.
Title: Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.
Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration.
Title: Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration.
Tnmd-deficient mouse tendon stem/progenitor cells exhibit significantly reduced adhesion to collagen type I.
Title: Tenomodulin regulates matrix remodeling of mouse tendon stem/progenitor cells in an ex vivo collagen I gel model.
Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes
Title: Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.
Tnmd is required for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing.
Title: Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing.
The results of enhanced tenogenic differentiation and neotendon formation indicated that Tnmd may serve not only as a tenogenic marker but also as a positive regulator of MSCs tenogenic differentiation, which might be applied to MSCs-mediated tendon regeneration.
Title: Enhanced tenogenic differentiation and tendon-like tissue formation by tenomodulin overexpression in murine mesenchymal stem cells.
our study demonstrates that Tnmd is required for proper tendon tissue adaptation to endurance running and aids in better understanding of the structural-functional relationships of tendon tissues.
Title: Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.
In vitro comparison of tenogenic differentiation potentials among bone marrow derived stem cells (BMSCs), adipose derived stem cells (ASCs), dermal fibroblasts (DFs) and tenocytes (TCs) of the same Tnmd transgenic mice. BMSCs exhibited the best tenogenic potential than other three cell types.
Title: Conditional tenomodulin overexpression favors tenogenic lineage differentiation of transgenic mouse derived cells.
Upon high-fat diet feeding, transgenic mice overexpressing Tnmd develop increased epididymal white adipose tissue (eWAT) mass, and preadipocytes derived from Tnmd transgenic mice display greater proliferation, consistent with elevated adipogenesis.
Title: Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

RH132574 (e-PCR)
- UniSTS:215857

1110017I01Rik (e-PCR), detects polymorphism
- UniSTS:265045

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within endothelial cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tenomodulin

Names: chondromodulin-1-like protein; chondromodulin-I-like protein; mChM1L; mTeM; myodulin; tendin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022322.2 → NP_071717.1 tenomodulin

See identical proteins and their annotated locations for NP_071717.1

Status: VALIDATED

Source sequence(s)

BC049944

Consensus CDS

CCDS30386.1

UniProtKB/Swiss-Prot

Q8CET4, Q9EP64

Related

ENSMUSP00000033602.9, ENSMUST00000033602.9

Conserved Domains (1) summary

smart01039
Location:93 → 186

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer