Sln sarcolipin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slnprovided by MGI
Official Full Name: sarcolipinprovided by MGI
Primary source: MGI:MGI:1913652
See related: Ensembl:ENSMUSG00000042045 AllianceGenome:MGI:1913652
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310045A07Rik
Summary: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
Expression: Biased expression in heart adult (RPKM 361.2), lung adult (RPKM 58.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.24 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (53757535..53761133)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (53850251..53853849)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reducing sarcolipin expression improves muscle metabolism in mdx mice.
Title: Reducing sarcolipin expression improves muscle metabolism in mdx mice.
Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice.
Title: Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice.
reducing expression of sarcolipin expression can improve the Cai2+ cycling and differentiation of dystrophic myoblasts
Title: Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy.
our findings demonstrate a critical role for SLN upregulation in dystrophic muscles and suggest that SLN can be viewed as a potential therapeutic target.
Title: Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology.
SLN overexpression is associated with severe muscle atrophy and weakness.
Title: Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.
SLN plays an important role in adaptive muscle remodeling potentially through calcineurin stimulation, which could have important implications for other muscle diseases and conditions
Title: Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload.
Cardiac function of Sln(Cre/+) mice was not significantly different from WT mice in all aspects that were examined.
Title: Heterozygous deletion of sarcolipin maintains normal cardiac function.
increased expression improves skeletal muscle performance during prolonged muscle activity by increasing store-operated calcium entry and muscle energetics
Title: Sarcolipin overexpression improves muscle energetics and reduces fatigue.
the N termini of SLN and PLB influence their respective unique functions
Title: The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport.
UCP1 and SLN are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress
Title: Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of ATPase-coupled calcium transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ATPase-coupled calcium transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ATPase-coupled calcium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of relaxation of muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcoplasmic reticulum calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sarcolipin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.