Acot6 acyl-CoA thioesterase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot6provided by MGI
Official Full Name: acyl-CoA thioesterase 6provided by MGI
Primary source: MGI:MGI:1921287
See related: Ensembl:ENSMUSG00000043487 AllianceGenome:MGI:1921287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A330054B07; 4632408A20Rik
Summary: Predicted to enable acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cytosol. Is expressed in respiratory system cartilage; sensory organ; skeleton; and tarsus. Orthologous to human ACOT6 (acyl-CoA thioesterase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 11.9), kidney adult (RPKM 8.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 39.04 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (84147538..84158128)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (84100654..84109783)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acot6 was identified as a target gene of the peroxisome proliferator-activated receptor alpha (PPARalpha) and is up-regulated in mouse liver in a PPARalpha-dependent manner.
Title: Peroxisomes contain a specific phytanoyl-CoA/pristanoyl-CoA thioesterase acting as a novel auxiliary enzyme in alpha- and beta-oxidation of methyl-branched fatty acids in mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in peroxisome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 6

NP_001405300.1

EC 3.1.2.2

NP_766168.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418371.1 → NP_001405300.1 acyl-coenzyme A thioesterase 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC125071
NM_172580.2 → NP_766168.1 acyl-coenzyme A thioesterase 6 isoform 1

See identical proteins and their annotated locations for NP_766168.1

Status: VALIDATED

Source sequence(s)

AC125071

Consensus CDS

CCDS26038.1

UniProtKB/Swiss-Prot

Q32Q92, Q3TQG7, Q8BXE0, Q8BYI3, Q99LZ0

UniProtKB/TrEMBL

B2RTE4

Related

ENSMUSP00000056131.4, ENSMUST00000056822.4

Conserved Domains (3) summary

COG0657
Location:83 → 374

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam04775
Location:17 → 137

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

pfam08840
Location:203 → 410

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal