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    Tbc1d15 TBC1 domain family, member 15 [ Mus musculus (house mouse) ]

    Gene ID: 66687, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tbc1d15provided by MGI
    Official Full Name
    TBC1 domain family, member 15provided by MGI
    Primary source
    MGI:MGI:1913937
    See related
    Ensembl:ENSMUSG00000020130 AllianceGenome:MGI:1913937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly6dl; Rab7-GAP; 4432405K22Rik
    Summary
    Enables GTPase activator activity. Involved in regulation of GTPase activity. Located in cytoplasm and extracellular region. Is expressed in brain; embryo; liver; spleen; and thymus. Orthologous to human TBC1D15 (TBC1 domain family member 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.0), bladder adult (RPKM 12.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 D2; 10 63.51 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115031459..115087343, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115197871..115251493, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27929 Neighboring gene predicted gene, 22070 Neighboring gene tryptophan hydroxylase 2 Neighboring gene STARR-seq mESC enhancer starr_27930 Neighboring gene STARR-seq mESC enhancer starr_27931 Neighboring gene STARR-seq mESC enhancer starr_27933 Neighboring gene STARR-positive B cell enhancer ABC_E3915 Neighboring gene predicted gene 8942 Neighboring gene STARR-positive B cell enhancer ABC_E3916 Neighboring gene RAB21, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury. Yu W, et al. Theranostics, 2020. PMID 33042281, Free PMC Article
    2. This is an addendum to the February 2000 article by Apostolopoulos et al., "Ly6d-L, a Cell Surface Ligand for Mouse Ly6d.". Sandrin MS, et al. Immunity, 2000 Dec. PMID 11163200
    3. Ly6d-L, a cell surface ligand for mouse Ly6d. Apostolopoulos J, et al. Immunity, 2000 Feb. PMID 10714688
    4. The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex. Feldman DE, et al. PLoS One, 2013. PMID 23468968, Free PMC Article
    5. TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7. Zhang XM, et al. Biochem Biophys Res Commun, 2005 Sep 16. PMID 16055087

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury.
      Title: TBC1D15/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury.
    2. nigericin-induced mitochondria fission was rescued by knockdown of either dynamin-related protein 1 or TBC1 domain family member 15 (TBC1D15), which are two distinct mitochondria fission regulators, only TBC1D15 restored the activity of the STING pathway, which indicates that inflammasome-activating signals curtail STING pathway activation via TBC1D15.
      Title: Stimulator of IFN genes-mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators.
    3. identify TBC1D15 as a Numb-associated protein and demonstrate that its amino-terminal domain disengages p53 from Numb, triggering p53 proteolysis and promoting self-renewal and pluripotency
      Title: The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex.
    4. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
      Title: Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence.
    5. TBC1D15 may be involved in Rab7-mediated late endosomal trafficking
      Title: TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    TBC1 domain family member 15
    Names
    GAP for RAB7
    GTPase-activating protein RAB7
    lymphocyte antigen 6, locus D ligand
    NP_001414153.1
    NP_001414154.1
    NP_001414155.1
    NP_079982.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427224.1 → NP_001414153.1  TBC1 domain family member 15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153825

    2. NM_001427225.1 → NP_001414154.1  TBC1 domain family member 15 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153825

    3. NM_001427226.1 → NP_001414155.1  TBC1 domain family member 15 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153825

    4. NM_025706.4 → NP_079982.3  TBC1 domain family member 15 isoform 2

      See identical proteins and their annotated locations for NP_079982.3

      Status: VALIDATED

      Source sequence(s)
      AC153825
      Consensus CDS
      CCDS24176.1
      UniProtKB/Swiss-Prot
      Q3UI41, Q9CXF4
      UniProtKB/TrEMBL
      Q4TVN0
      Related
      ENSMUSP00000020339.9, ENSMUST00000020339.10
      Conserved Domains (2) summary
      pfam12068
      Location:8 → 224
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:326 → 561
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      115031459..115087343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXF4.1 GenPept UniProtKB/Swiss-Prot:Q9CXF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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