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    B4galt3 beta-1,4-galactosyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494342, updated on 2-May-2024

    Summary

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    Official Symbol
    B4galt3provided by RGD
    Official Full Name
    beta-1,4-galactosyltransferase 3provided by RGD
    Primary source
    RGD:1359221
    See related
    Ensembl:ENSRNOG00000003551 AllianceGenome:RGD:1359221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable galactosyltransferase activity. Predicted to be involved in galactosylceramide biosynthetic process and glycosylation. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 147.5), Spleen (RPKM 99.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86223827..86229886)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83691378..83697448)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89643847..89649880)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Fc epsilon receptor Ig Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 4 Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin specific peptidase 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3. Almeida R, et al. J Biol Chem, 1997 Dec 19. PMID 9405390
    2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72586

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosamine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactosylceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 3
    Names
    N-acetyllactosamine synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
    b4Gal-T3
    beta-1,4-GalTase 3
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
    beta4Gal-T3
    nal synthase
    neolactotriaosylceramide beta-1,4-galactosyltransferase
    NP_001009539.1
    XP_006250315.1
    XP_006250316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009539.2 → NP_001009539.1  beta-1,4-galactosyltransferase 3

      See identical proteins and their annotated locations for NP_001009539.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6P768
      UniProtKB/TrEMBL
      A0A8I6ADZ3, A6JFW4
      Related
      ENSRNOP00000090652.1, ENSRNOT00000108060.1
      Conserved Domains (1) summary
      cd00899
      Location:124 → 343
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. NM_001429941.1 → NP_001416870.1  beta-1,4-galactosyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    3. NM_001429942.1 → NP_001416871.1  beta-1,4-galactosyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    4. NM_001429943.1 → NP_001416872.1  beta-1,4-galactosyltransferase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86223827..86229886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250254.5 → XP_006250316.1  beta-1,4-galactosyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_006250316.1

      UniProtKB/Swiss-Prot
      Q6P768
      UniProtKB/TrEMBL
      A0A8I6ADZ3, A6JFW4
      Conserved Domains (1) summary
      cd00899
      Location:124 → 343
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. XM_006250253.5 → XP_006250315.1  beta-1,4-galactosyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_006250315.1

      UniProtKB/Swiss-Prot
      Q6P768
      UniProtKB/TrEMBL
      A0A8I6ADZ3, A6JFW4
      Related
      ENSRNOP00000004735.4
      Conserved Domains (1) summary
      cd00899
      Location:124 → 343
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P768.1 GenPept UniProtKB/Swiss-Prot:Q6P768

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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