Tnni2 troponin I2, fast skeletal type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnni2provided by RGD
Official Full Name: troponin I2, fast skeletal typeprovided by RGD
Primary source: RGD:62050
See related: Ensembl:ENSRNOG00000020276 AllianceGenome:RGD:62050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable troponin T binding activity. Predicted to contribute to actin binding activity. Involved in regulation of muscle contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita and distal arthrogryposis type 2B1. Orthologous to human TNNI2 (troponin I2, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 67837.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (206882358..207027034)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (197595012..197597554)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (215609110..215611652)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Troponin I interaction with calcium and Troponin C in cardiac muscle
Title: The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR.
The effects of reactive oxygen species on tryptophan residues in alpha skeletal actin and troponin I, was investigated.
Title: Quantitative evaluation of tryptophan oxidation in actin and troponin I from skeletal muscles using a rat model of acute oxidative stress.
Release of fast sTnI consistent with load-induced injury of fast glycolytic fibres of inspiratory muscles, probably diaphragm. May provide insights into molecular basis of respiratory muscle dysfunction. Marker of respiratory muscle fatigue.
Title: Respiratory muscle injury, fatigue and serum skeletal troponin I in rat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
contributes_to actin binding	ISO Inferred from Sequence Orthology more info
enables troponin T binding	IEA Inferred from Electronic Annotation more info
enables troponin T binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in relaxation of skeletal muscle	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IDA Inferred from Direct Assay more info	PubMed
part_of troponin complex	IEA Inferred from Electronic Annotation more info
part_of troponin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: troponin I, fast skeletal muscle

Names: troponin 1, type 2; troponin I type 2 (skeletal, fast); troponin I, skeletal, fast 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.