Dcun1d5 defective in cullin neddylation 1 domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcun1d5provided by RGD
Official Full Name: defective in cullin neddylation 1 domain containing 5provided by RGD
Primary source: RGD:1307008
See related: Ensembl:ENSRNOG00000008390 AllianceGenome:RGD:1307008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307008
Summary: Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including positive regulation of protein modification by small protein conjugation or removal; protein neddylation; and regulation of cell growth. Located in nucleus. Orthologous to human DCUN1D5 (defective in cullin neddylation 1 domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 254.9), Muscle (RPKM 206.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (12697160..12718242)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (4412266..4433380)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (5437071..5458152)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE119287 (e-PCR)
- UniSTS:249142

RH138722 (e-PCR)
- UniSTS:220809

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	IEA Inferred from Electronic Annotation more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein neddylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DCN1-like protein 5

Names: DCN1, defective in cullin neddylation 1, domain containing 5; DCUN1 domain-containing protein 5; defective in cullin neddylation protein 1-like protein 5; squamous cell carcinoma-related oncogene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.