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    Macir macrophage immunometabolism regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501195, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Macirprovided by RGD
    Official Full Name
    macrophage immunometabolism regulatorprovided by RGD
    Primary source
    RGD:1562136
    See related
    Ensembl:ENSRNOG00000032398 AllianceGenome:RGD:1562136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562136
    Summary
    Predicted to be involved in negative regulation of cytokine production involved in inflammatory response; negative regulation of fibroblast migration; and negative regulation of inflammatory response. Predicted to be located in ciliary transition zone and cytoplasm. Orthologous to human MACIR (macrophage immunometabolism regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 219.5), Muscle (RPKM 139.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Macir in Genome Data Viewer
    Location:
    9q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (105868072..105888128)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (98420760..98440818)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (111327333..111347428)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene transfer RNA proline (anticodon AGG) 31 Neighboring gene uncharacterized LOC108351978 Neighboring gene uncharacterized LOC134480423

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation. Dorris ER, et al. J Immunol, 2019 Feb 15. PMID 30659109
    2. C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. Muthana M, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26316022, Free PMC Article
    3. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Wright KJ, et al. Genes Dev, 2011 Nov 15. PMID 22085962, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    macrophage immunometabolism regulator
    Names
    UNC119-binding protein C5orf30 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109086.1 → NP_001102556.1  macrophage immunometabolism regulator

      See identical proteins and their annotated locations for NP_001102556.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473997
      UniProtKB/TrEMBL
      A6JR86, D3ZPS9
      Related
      ENSRNOP00000041389.3, ENSRNOT00000045749.5
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      105868072..105888128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596608.3 → XP_017452097.1  macrophage immunometabolism regulator isoform X1

      UniProtKB/TrEMBL
      A6JR86, D3ZPS9
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    2. XM_039084127.2 → XP_038940055.1  macrophage immunometabolism regulator isoform X1

      UniProtKB/TrEMBL
      A6JR86, D3ZPS9
      Related
      ENSRNOP00000083706.1
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    3. XM_017596609.3 → XP_017452098.1  macrophage immunometabolism regulator isoform X1

      UniProtKB/TrEMBL
      A6JR86, D3ZPS9
      Related
      ENSRNOP00000093274.1
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog
    Nucleotide Protein Strain
    Heading Accession and Version

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