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    Tmcc2 transmembrane and coiled-coil domain family 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305095, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tmcc2provided by RGD
    Official Full Name
    transmembrane and coiled-coil domain family 2provided by RGD
    Primary source
    RGD:1311960
    See related
    Ensembl:ENSRNOG00000000033 AllianceGenome:RGD:1311960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311960
    Summary
    Predicted to be involved in amyloid precursor protein metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Orthologous to human TMCC2 (transmembrane and coiled-coil domain family 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 290.1), Lung (RPKM 149.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmcc2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46346177..46383862, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43794029..43831716, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (49132685..49169771, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 8A Neighboring gene uncharacterized LOC120096185 Neighboring gene NUAK family kinase 2 Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene RB binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene transmembrane protein 81

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β. Hopkins PC, et al. J Alzheimers Dis, 2011. PMID 21593558
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in amyloid precursor protein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amyloid precursor protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domains protein 2
    Names
    transmembrane and coiled-coil domains 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305128.1 → NP_001292057.1  transmembrane and coiled-coil domains protein 2

      See identical proteins and their annotated locations for NP_001292057.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC49, D3ZE26
      Related
      ENSRNOP00000000036.3, ENSRNOT00000000036.6
      Conserved Domains (1) summary
      pfam10267
      Location:283 → 692
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      46346177..46383862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272405.1 → XP_063128475.1  transmembrane and coiled-coil domains protein 2 isoform X1

    2. XM_003751237.6 → XP_003751285.1  transmembrane and coiled-coil domains protein 2 isoform X2

      See identical proteins and their annotated locations for XP_003751285.1

      Conserved Domains (1) summary
      pfam10267
      Location:205 → 614
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_063272404.1 → XP_063128474.1  transmembrane and coiled-coil domains protein 2 isoform X1

    4. XM_006249803.5 → XP_006249865.1  transmembrane and coiled-coil domains protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006249865.1

      UniProtKB/TrEMBL
      A0A8I5ZVA9
      Related
      ENSRNOP00000082636.1
      Conserved Domains (1) summary
      pfam10267
      Location:50 → 456
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    5. XM_063272406.1 → XP_063128476.1  transmembrane and coiled-coil domains protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A0X9

    6. XM_063272407.1 → XP_063128477.1  transmembrane and coiled-coil domains protein 2 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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