Lactb lactamase, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lactbprovided by RGD
Official Full Name: lactamase, betaprovided by RGD
Primary source: RGD:1304788
See related: Ensembl:ENSRNOG00000018081 AllianceGenome:RGD:1304788
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity. Predicted to be involved in proteolysis and regulation of lipid metabolic process. Predicted to be located in cytosol and mitochondrion. Orthologous to human LACTB (lactamase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 316.9), Liver (RPKM 289.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (76452679..76469986, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (67571504..67587592, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (72750174..72766307, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LACTB resides in the mitochondrial intermembrane space and forms a soluble high molecular weight homopolymer.
Title: LACTB is a filament-forming protein localized in mitochondria.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine beta-lactamase-like protein LACTB, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106833.1 → NP_001100303.1 serine beta-lactamase-like protein LACTB, mitochondrial

See identical proteins and their annotated locations for NP_001100303.1

Status: PROVISIONAL

Source sequence(s)

CH474041

UniProtKB/TrEMBL

A6KEZ7, D3ZFJ6

Related

ENSRNOP00000024452.4, ENSRNOT00000024452.7

Conserved Domains (1) summary

pfam00144
Location:110 → 527

Beta-lactamase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

76452679..76469986 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766242.4 → XP_008764464.1 serine beta-lactamase-like protein LACTB, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5ZR42

Related

ENSRNOP00000080609.1

Conserved Domains (1) summary

pfam00144
Location:110 → 245

Beta-lactamase; Beta-lactamase
XM_063265165.1 → XP_063121235.1 serine beta-lactamase-like protein LACTB, mitochondrial isoform X2