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    Tnfrsf9 TNF receptor superfamily member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500590, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tnfrsf9provided by RGD
    Official Full Name
    TNF receptor superfamily member 9provided by RGD
    Primary source
    RGD:1598208
    See related
    Ensembl:ENSRNOG00000036942 AllianceGenome:RGD:1598208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    4-1BB
    Summary
    Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 24.7), Thymus (RPKM 21.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166664494..166690834)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161381662..161408003)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (168009245..168035813)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene uncharacterized LOC102556316 Neighboring gene Parkinsonism associated deglycase Neighboring gene uncharacterized LOC134479048 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene silencing of 4-1BB by RNA interference inhibits acute rejection in rats with liver transplantation. Shi Y, et al. Biomed Res Int, 2013. PMID 23484089, Free PMC Article
    2. Expression of CD137 in the cerebral artery after experimental subarachnoid hemorrhage in rats: a pilot study. Zhang J, et al. Brain Res, 2011 Apr 22. PMID 21352817
    3. Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. Haga T, et al. J Mol Cell Cardiol, 2009 May. PMID 19233196
    4. Molecular cloning and protein characterization of swine 4-1BB. Zhao X, et al. Vet Immunol Immunopathol, 2013 May 15. PMID 23453329
    5. Characterisation of soluble murine CD137 and its association with systemic lupus. Shao Z, et al. Mol Immunol, 2008 Sep. PMID 18640726

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gene silencing of 4-1BB by RNA interference inhibits the acute rejection in rats with liver transplantation.
      Title: Gene silencing of 4-1BB by RNA interference inhibits acute rejection in rats with liver transplantation.
    2. Upregulation of CD137 in the cerebral arterial wall may be important in the development of cerebral vasospasm following subarachnoid hemorrhage.
      Title: Expression of CD137 in the cerebral artery after experimental subarachnoid hemorrhage in rats: a pilot study.
    3. Blockade of T cell activation through the 4-1BB/4-1BBL pathway regulates development of experimental autoimmune myocarditis.
      Title: Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC114552

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 9
    Names
    tumor necrosis factor receptor superfamily, member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025773.1 → NP_001020944.1  tumor necrosis factor receptor superfamily member 9 precursor

      See identical proteins and their annotated locations for NP_001020944.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097483
      UniProtKB/TrEMBL
      A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
      Related
      ENSRNOP00000052371.3, ENSRNOT00000055506.5
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      166664494..166690834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764282.3 → XP_008762504.1  tumor necrosis factor receptor superfamily member 9 isoform X1

      See identical proteins and their annotated locations for XP_008762504.1

      UniProtKB/TrEMBL
      A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

    2. XM_039110648.2 → XP_038966576.1  tumor necrosis factor receptor superfamily member 9 isoform X2

      Conserved Domains (2) summary
      cd00185
      Location:23 → 44
      TNFRSF; CRD1 [structural motif]
      cl22855
      Location:23 → 117
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    3. XM_039110649.2 → XP_038966577.1  tumor necrosis factor receptor superfamily member 9 isoform X3

      Conserved Domains (2) summary
      cd00185
      Location:23 → 44
      TNFRSF; CRD1 [structural motif]
      cl22855
      Location:23 → 138
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    4. XM_039110647.2 → XP_038966575.1  tumor necrosis factor receptor superfamily member 9 isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

    5. XM_006239472.5 → XP_006239534.1  tumor necrosis factor receptor superfamily member 9 isoform X1

      See identical proteins and their annotated locations for XP_006239534.1

      UniProtKB/TrEMBL
      A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
      Related
      ENSRNOP00000074761.2
      Conserved Domains (1) summary
      cd13410
      Location:23 → 160
      TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
    Nucleotide Protein Strain
    Heading Accession and Version

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