Sult2b1 sulfotransferase family 2B member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sult2b1provided by RGD
Official Full Name: sulfotransferase family 2B member 1provided by RGD
Primary source: RGD:1308882
See related: Ensembl:ENSRNOG00000021046 AllianceGenome:RGD:1308882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ST2B1
Summary: Predicted to enable nucleic acid binding activity; steroid binding activity; and steroid sulfotransferase activity. Predicted to be involved in several processes, including 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cholesterol metabolic process; and positive regulation of epidermal cell differentiation. Predicted to act upstream of or within sulfate assimilation. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14. Orthologous to human SULT2B1 (sulfotransferase family 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 64.7), Testes (RPKM 12.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105336614..105397744, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96200155..96261295, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101712254..101774683, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Since 1'-hydroxyestragole exposure readily produced DNA injury in B-13/H cells, these data suggest that cholangiocarcinomas generated in rats fed estragole may be dependent, in part, on SULT2B1 activation of the 1'-hydroxyestragole metabolite.
Title: Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.

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General gene information

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Markers

BM387038 (e-PCR)
- UniSTS:261241

AW523314 (e-PCR)
- UniSTS:261759

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables steroid hormone binding	ISO Inferred from Sequence Orthology more info
enables steroid sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sulfate assimilation	ISO Inferred from Sequence Orthology more info
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sulfotransferase 2B1

Names: alcohol sulfotransferase; hydroxysteroid sulfotransferase 2; sulfotransferase 2B; sulfotransferase family, cytosolic, 2B, member 1

NP_001034754.1

EC 2.8.2.2

XP_006229093.1

EC 2.8.2.2

XP_063140307.1

EC 2.8.2.2

XP_063140316.1

EC 2.8.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.