Vps13c vacuolar protein sorting 13 homolog C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vps13cprovided by RGD
Official Full Name: vacuolar protein sorting 13 homolog Cprovided by RGD
Primary source: RGD:1560364
See related: Ensembl:ENSRNOG00000030213 AllianceGenome:RGD:1560364
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560364
Summary: Predicted to be involved in mitochondrion organization and negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization. Predicted to act upstream of or within response to insulin. Predicted to be located in cytosol; dense core granule membrane; and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Parkinson's disease 23. Orthologous to human VPS13C (vacuolar protein sorting 13 homolog C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 205.8), Spleen (RPKM 170.1) and 9 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (77359499..77533009)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (68478366..68651893)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (73682814..73843290)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dense core granule membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_056984521.2 → XP_056840501.1 intermembrane lipid transfer protein VPS13C isoform X1

Related

ENSRNOP00000054331.4
XM_056984523.2 → XP_056840503.1 intermembrane lipid transfer protein VPS13C isoform X3

UniProtKB/TrEMBL

A0A8I5ZYI1

Related

ENSRNOP00000084628.1
XM_063266344.1 → XP_063122414.1 intermembrane lipid transfer protein VPS13C isoform X5
XM_056984522.2 → XP_056840502.1 intermembrane lipid transfer protein VPS13C isoform X2

Related

ENSRNOP00000079458.1
XM_056984524.2 → XP_056840504.1 intermembrane lipid transfer protein VPS13C isoform X4