Padi3 peptidyl arginine deiminase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Padi3provided by RGD
Official Full Name: peptidyl arginine deiminase 3provided by RGD
Primary source: RGD:3289
See related: Ensembl:ENSRNOG00000006950 AllianceGenome:RGD:3289
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pdi3
Summary: Enables protein-arginine deiminase activity. Involved in protein citrullination. Predicted to be active in cytoplasm and nucleus. Orthologous to human PADI3 (peptidyl arginine deiminase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 2.9), Muscle (RPKM 2.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (158372764..158400193, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (153089717..153117146, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (159309000..159336429, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-arginine deiminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine deiminase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine deiminase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine deiminase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arginine deiminase pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein-arginine deiminase type-3

Names: peptidyl arginine deiminase, type 3; peptidyl arginine deiminase, type III; peptidylarginine deiminase III; protein-arginine deiminase type III

NP_058926.1

EC 3.5.3.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017230.2 → NP_058926.1 protein-arginine deiminase type-3

See identical proteins and their annotated locations for NP_058926.1

Status: PROVISIONAL

Source sequence(s)

D88034

UniProtKB/Swiss-Prot

P70708

UniProtKB/TrEMBL

A6ITP4, G3V6V2

Related

ENSRNOP00000009230.1, ENSRNOT00000009230.3

Conserved Domains (3) summary

pfam03068
Location:286 → 661

PAD; Protein-arginine deiminase (PAD)

pfam08526
Location:1 → 113

PAD_N; Protein-arginine deiminase (PAD) N-terminal domain

pfam08527
Location:115 → 272

PAD_M; Protein-arginine deiminase (PAD) middle domain