U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Adipor2 adiponectin receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312670, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Adipor2provided by RGD
    Official Full Name
    adiponectin receptor 2provided by RGD
    Primary source
    RGD:1307891
    See related
    Ensembl:ENSRNOG00000007990 AllianceGenome:RGD:1307891
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable adipokinetic hormone receptor activity; adiponectin binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of hepatic stellate cell migration; positive regulation of glucose import; and response to fructose. Predicted to be intrinsic component of plasma membrane. Predicted to be active in plasma membrane. Biomarker of end stage renal disease; fatty liver disease (multiple); glucose metabolism disease (multiple); and obesity. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease and type 2 diabetes mellitus. Orthologous to human ADIPOR2 (adiponectin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 685.2), Liver (RPKM 620.4) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Adipor2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (154195440..154261141, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (152524604..152588848, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (151412135..151480108, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene uncharacterized LOC134486630 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene Wnt family member 5B Neighboring gene F-box and leucine-rich repeat protein 14 Neighboring gene uncharacterized LOC134486631

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats. Li J, et al. J Diabetes Res, 2018. PMID 30225267, Free PMC Article
    2. Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet. de Sousa AR, et al. Food Res Int, 2018 Oct. PMID 30131158
    3. Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease. Lei L, et al. Clin Exp Pharmacol Physiol, 2018 Aug. PMID 29569260
    4. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. Wang M, et al. Sci Rep, 2016 May 25. PMID 27220557, Free PMC Article
    5. Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway. Li Z, et al. Int J Clin Exp Med, 2015. PMID 26770322, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
      Title: The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
    2. In a model of NAFLD, Adipor2 was primarily expressed in the cytoplasm of hepatocytes.
      Title: Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD.
    3. Adipo R2 expression in kidney is increased in chronic renal failure
      Title: Changes of adiponectin and its receptors in rats following chronic renal failure.
    4. Adiponectin functions as a promoter of Adiponectin functions as a promoter of salivary secretion in rat submandibular glands via activation of Adiponectin receptors, AMPK, and paracellular permeability.
      Title: Adiponectin increases secretion of rat submandibular gland via adiponectin receptors-mediated AMPK signaling.
    5. AdipoR1 and AdipoR2 gene expression is regulated by thyroid hormones in hypo- and hyperthyroidism.
      Title: AdipoR1 and AdipoR2 gene expression are regulated by thyroid hormones in adipose tissue.
    6. The results demonstrate that human biosynthetic insulin down-regulates both AdipoR1 and AdipoR2 mRNAs levels in a biphasic manner in L6 and PAC1 cells.
      Title: Insulin-regulated expression of adiponectin receptors in muscle and fat cells.
    7. Telmisartan upregulates myocardial expression of Adipor2 in type 2 diabetic rats.
      Title: Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats.
    8. the effects of Caloric restriction on adiposity and gene expression of adiponectin, its receptors (AdipoR2 in adipose tissue and in isolated adipocytes
      Title: Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats.
    9. AdipoR2 and insulin receptor substrate isoforms might be crucially important regulators for the synthesis and oxidation of fatty acids in the liver of Nonalcoholic steatohepatitis
      Title: Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model.
    10. investigation of expression and physiological role of AdipoR2 (also AdipoR1 and adopinectin) in adrenal cortex
      Title: Adiponectin and adiponectin receptor system in the rat adrenal gland: ontogenetic and physiologic regulation, and its involvement in regulating adrenocortical growth and steroidogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables adipokinetic hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adiponectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hepatic stellate cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to amine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to fructose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adiponectin receptor protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037979.1 → NP_001033068.1  adiponectin receptor protein 2

      See identical proteins and their annotated locations for NP_001033068.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ148392
      UniProtKB/TrEMBL
      Q3YAF7
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      154195440..154261141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237184.5 → XP_006237246.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006237246.1

      UniProtKB/TrEMBL
      A6IL82, G3V707
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    2. XM_063286113.1 → XP_063142183.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/TrEMBL
      A6IL82, G3V707

    3. XM_063286112.1 → XP_063142182.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/TrEMBL
      A6IL82, G3V707

    4. XM_039107651.2 → XP_038963579.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/TrEMBL
      A6IL82, G3V707
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related

    5. XM_063286114.1 → XP_063142184.1  adiponectin receptor protein 2 isoform X1

      UniProtKB/TrEMBL
      A6IL82, G3V707

    6. XM_006237183.4 → XP_006237245.1  adiponectin receptor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006237245.1

      UniProtKB/TrEMBL
      A6IL82, G3V707
      Related
      ENSRNOP00000010556.3
      Conserved Domains (1) summary
      pfam03006
      Location:140 → 363
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous