Adss1 adenylosuccinate synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adss1provided by RGD
Official Full Name: adenylosuccinate synthase 1provided by RGD
Primary source: RGD:1590342
See related: Ensembl:ENSRNOG00000046763 AllianceGenome:RGD:1590342
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AdSS 1; Adssl1
Summary: Enables several functions, including GTPase activity; actin filament binding activity; and adenylosuccinate synthase activity. Involved in several processes, including alpha-amino acid metabolic process; cellular response to electrical stimulus; and purine ribonucleoside monophosphate metabolic process. Predicted to be active in cytoplasm. Biomarker of sarcoma. Orthologous to human ADSS1 (adenylosuccinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 2548.0) and Heart (RPKM 684.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (137500549..137523087)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (131679795..131702012)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (137184818..137206694)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF406314 (e-PCR)
- UniSTS:248334

Adssl1 (e-PCR), detects polymorphism
- UniSTS:508560

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables adenylosuccinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylosuccinate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylosuccinate synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' AMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in AMP salvage	ISO Inferred from Sequence Orthology more info
involved_in IMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutamine metabolic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within purine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylosuccinate synthetase isozyme 1

Names: AMPSase 1; IMP--aspartate ligase 1; adenylosuccinate synthase like 1; adenylosuccinate synthetase, muscle isozyme

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

137500549..137523087

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039113409.2 → XP_038969337.1 adenylosuccinate synthetase isozyme 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A7H6

Related

ENSRNOP00000088257.1

Conserved Domains (1) summary

pfam00709
Location:38 → 428

Adenylsucc_synt; Adenylosuccinate synthetase
XM_003750237.5 → XP_003750285.1 adenylosuccinate synthetase isozyme 1 isoform X1

See identical proteins and their annotated locations for XP_003750285.1

UniProtKB/TrEMBL

A0A8I6G9X7, A6KBV5, M0R629

Related

ENSRNOP00000064866.1

Conserved Domains (1) summary

pfam00709
Location:35 → 454

Adenylsucc_synt; Adenylosuccinate synthetase