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    Btbd10 BTB domain containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308890, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Btbd10provided by RGD
    Official Full Name
    BTB domain containing 10provided by RGD
    Primary source
    RGD:1306301
    See related
    Ensembl:ENSRNOG00000014341 AllianceGenome:RGD:1306301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306301
    Summary
    Involved in type B pancreatic cell proliferation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human BTBD10 (BTB domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 79.4), Brain (RPKM 67.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btbd10 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (176865817..176923663, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167431311..167489320, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178138562..178196551, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099909 Neighboring gene basic helix-loop-helix ARNT like 1 Neighboring gene uncharacterized LOC134484822 Neighboring gene RNA, U6 small nuclear 26 Neighboring gene parathyroid hormone Neighboring gene enolase 1, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Early changes in GMRP1 after intracerebral hemorrhage: involvement in brain damage and cell apoptosis. Wang X, et al. Acta Neurochir Suppl, 2013. PMID 23564125
    2. Involvement of GMRP1, a novel mediator of Akt pathway, in brain damage after intracerebral hemorrhage. Zheng M, et al. Int J Clin Exp Pathol, 2013. PMID 23330007, Free PMC Article
    3. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. Wang X, et al. Diabetologia, 2011 Apr. PMID 21267538
    4. A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Nawa M, et al. Cell Signal, 2008 Mar. PMID 18160256
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105916

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 10
    Names
    BTB (POZ) domain containing 10
    K+ channel tetramerization protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014022.2 → NP_001014044.1  BTB/POZ domain-containing protein 10 isoform b

      See identical proteins and their annotated locations for NP_001014044.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQE4, Q5EAP0
      Conserved Domains (1) summary
      cd18385
      Location:117 → 226
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    2. NM_001399401.1 → NP_001386330.1  BTB/POZ domain-containing protein 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQE4, F7EZ61
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    3. NM_001399402.1 → NP_001386331.1  BTB/POZ domain-containing protein 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQE4, F7EZ61
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    4. NM_001399403.1 → NP_001386332.1  BTB/POZ domain-containing protein 10 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQE4, Q5EAP0
      Conserved Domains (1) summary
      cd18385
      Location:117 → 226
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    5. NM_001399404.1 → NP_001386333.1  BTB/POZ domain-containing protein 10 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQE4, Q5EAP0
      Related
      ENSRNOP00000096128.1, ENSRNOT00000099504.1
      Conserved Domains (1) summary
      cd18385
      Location:117 → 226
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      176865817..176923663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113416.2 → XP_038969344.1  BTB/POZ domain-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQE4, Q5EAP0
      Conserved Domains (1) summary
      cd18385
      Location:117 → 226
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    2. XM_017589192.2 → XP_017444681.1  BTB/POZ domain-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQE4, F7EZ61
      Related
      ENSRNOP00000060287.2
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    3. XM_039113392.2 → XP_038969320.1  BTB/POZ domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZA0, A0A8I6AQE4
      Related
      ENSRNOP00000070965.1
      Conserved Domains (1) summary
      cd18385
      Location:154 → 263
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    4. XM_039113386.2 → XP_038969314.1  BTB/POZ domain-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQE4, F7EZ61
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    5. XM_006230038.5 → XP_006230100.1  BTB/POZ domain-containing protein 10 isoform X2

      See identical proteins and their annotated locations for XP_006230100.1

      UniProtKB/TrEMBL
      A0A8I6AQE4, F7EZ61
      Conserved Domains (1) summary
      cd18385
      Location:165 → 274
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)

    6. XM_063262859.1 → XP_063118929.1  BTB/POZ domain-containing protein 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQE4, F7EZ61

    7. XM_006230033.5 → XP_006230095.1  BTB/POZ domain-containing protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2B2, A0A8I6AQE4
      Related
      ENSRNOP00000086484.1
      Conserved Domains (1) summary
      pfam16017
      Location:209 → 438
      BTB_3; BTB/POZ domain

    8. XM_039113428.2 → XP_038969356.1  BTB/POZ domain-containing protein 10 isoform X5

      Conserved Domains (1) summary
      cd18385
      Location:173 → 282
      BTB_POZ_BTBD10_GMRP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10)
    Nucleotide Protein Strain
    Heading Accession and Version

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