Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cited1provided by RGD
Official Full Name: Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1provided by RGD
Primary source: RGD:620781
See related: Ensembl:ENSRNOG00000003189 AllianceGenome:RGD:620781
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Msg1
Summary: Predicted to enable several functions, including LBD domain binding activity; co-SMAD binding activity; and protein C-terminus binding activity. Involved in several processes, including branching involved in ureteric bud morphogenesis; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; and regulation of transcription, DNA-templated. Located in cytoplasm. Orthologous to human CITED1 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 88.8), Heart (RPKM 41.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (71390328..71395023, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (67350376..67355072, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (72128996..72133692, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggests that CoCl2-induced up-regulation of p300 expression promotes neuronal-like PC12 cell damage.
Title: CoCl2-induced expression of p300 promotes neuronal-like PC12 cell damage.
CITED1 could play a role in Wilms' tumor initiation and pathogenesis.
Title: CITED1 expression in Wilms' tumor and embryonic kidney.
Cited1 regulates cell differentiation and survival in the metanephros during nephrogenesis.
Title: Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables LBD domain binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic axis specification	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer development	ISO Inferred from Sequence Orthology more info
involved_in melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in melanin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in melanocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
involved_in pigmentation	ISO Inferred from Sequence Orthology more info
involved_in pigmentation	ISS Inferred from Sequence or Structural Similarity more info
involved_in placenta development	ISO Inferred from Sequence Orthology more info
involved_in placenta development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-11	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-11	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-2	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-2	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-4	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-6	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-6	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-9	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-9	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to parathyroid hormone	ISO Inferred from Sequence Orthology more info
involved_in response to parathyroid hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to transforming growth factor beta	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spongiotrophoblast layer development	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cbp/p300-interacting transactivator 1

Names: melanocyte-specific gene 1 protein

NP_742052.2

EC 3.5.1.98

XP_006257160.1

EC 3.5.1.98

XP_006257161.1

EC 3.5.1.98

XP_006257162.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.