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    Chst10 carbohydrate sulfotransferase 10 [ Mus musculus (house mouse) ]

    Gene ID: 98388, updated on 12-May-2024

    Summary

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    Official Symbol
    Chst10provided by MGI
    Official Full Name
    carbohydrate sulfotransferase 10provided by MGI
    Primary source
    MGI:MGI:2138283
    See related
    Ensembl:ENSMUSG00000026080 AllianceGenome:MGI:2138283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ST; Hnk-1st
    Summary
    Enables sulfotransferase activity. Acts upstream of or within learning and long-term memory. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in brain. Orthologous to human CHST10 (carbohydrate sulfotransferase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 8.7), CNS E18 (RPKM 7.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chst10 in Genome Data Viewer
    Location:
    1 B; 1 17.24 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38902948..38937256, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38863867..38898177, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38752992-38753101 Neighboring gene predicted gene, 57569 Neighboring gene STARR-seq mESC enhancer starr_00700 Neighboring gene STARR-positive B cell enhancer ABC_E8770 Neighboring gene LON peptidase N-terminal domain and ring finger 2 Neighboring gene STARR-seq mESC enhancer starr_00701 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38942945-38943098 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene neuromedin S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. Gurevicius K, et al. Mol Cell Neurosci, 2007 Feb. PMID 17157030
    2. HNK-1 sulfotransferase null mice express glucuronyl glycoconjugates and show normal cerebellar granule neuron migration in vivo and in vitro. Chou DK, et al. J Neurochem, 2002 Sep. PMID 12358771
    3. In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. Suzuki-Anekoji M, et al. J Biol Chem, 2013 Feb 15. PMID 23269668, Free PMC Article
    4. Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration. Chou DK, et al. J Neurochem, 2004 Sep. PMID 15341523
    5. Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. Senn C, et al. Mol Cell Neurosci, 2002 Aug. PMID 12213450

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chst10 likely functions in widespread regulation of steroid hormones in vivo
      Title: In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse.
    2. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.
      Title: Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.
    3. This study conclude that in ST-/- mice which show morphological, electrophysiological and behavioural abnormalities, the ECS is reduced and its geometry altered.
      Title: Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables HNK-1 sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 10
    Names
    HNK-1 sulfotransferase
    HNK1ST
    NP_001355709.1
    NP_660124.3
    XP_006496427.1
    XP_030099743.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368780.1 → NP_001355709.1  carbohydrate sulfotransferase 10

      Status: VALIDATED

      Source sequence(s)
      AC101277, AC124699
      UniProtKB/Swiss-Prot
      Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40
      UniProtKB/TrEMBL
      A0A0A6YVW5
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    2. NM_145142.3 → NP_660124.3  carbohydrate sulfotransferase 10

      Status: VALIDATED

      Source sequence(s)
      AC101277, AC124699
      Consensus CDS
      CCDS14901.1
      UniProtKB/Swiss-Prot
      Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40
      UniProtKB/TrEMBL
      A0A0A6YVW5
      Related
      ENSMUSP00000027249.8, ENSMUST00000027249.13
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      38902948..38937256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496364.5 → XP_006496427.1  carbohydrate sulfotransferase 10 isoform X1

      See identical proteins and their annotated locations for XP_006496427.1

      UniProtKB/TrEMBL
      A0A0A6YVW5, A2RSS2
      Conserved Domains (1) summary
      pfam03567
      Location:134 → 366
      Sulfotransfer_2; Sulfotransferase family

    2. XM_030243883.1 → XP_030099743.1  carbohydrate sulfotransferase 10 isoform X2

      UniProtKB/Swiss-Prot
      Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40
      UniProtKB/TrEMBL
      A0A0A6YVW5
      Conserved Domains (1) summary
      pfam03567
      Location:116 → 348
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGK7.2 GenPept UniProtKB/Swiss-Prot:Q6PGK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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