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    Cidec cell death-inducing DFFA-like effector c [ Mus musculus (house mouse) ]

    Gene ID: 14311, updated on 5-Mar-2024

    Summary

    Official Symbol
    Cidecprovided by MGI
    Official Full Name
    cell death-inducing DFFA-like effector cprovided by MGI
    Primary source
    MGI:MGI:95585
    See related
    Ensembl:ENSMUSG00000030278 AllianceGenome:MGI:95585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fsp27; CIDE-3
    Summary
    Predicted to be involved in execution phase of apoptosis; lipid droplet organization; and regulation of apoptotic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; endocrine gland; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5. Orthologous to human CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 1173.4), genital fat pad adult (RPKM 661.3) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    6 E3; 6 52.76 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113401595..113412721, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113424634..113435760, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 4 Neighboring gene tubulin tyrosine ligase-like family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1706 Neighboring gene RNA pseudouridylate synthase domain containing 3 Neighboring gene predicted gene, 52871 Neighboring gene STARR-positive B cell enhancer ABC_E8122 Neighboring gene jagunal homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113408068-113408221 Neighboring gene interleukin 17 receptor E Neighboring gene predicted gene, 52872

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid transfer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid droplet fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid droplet fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lipid transferase CIDEC
    Names
    CIDE-3alpha
    cell death activator CIDE-3
    cell death-inducing DFFA-like effector protein C
    fat specific gene 27
    fat-specific protein FSP27

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301295.1NP_001288224.1  lipid transferase CIDEC isoform 1

      See identical proteins and their annotated locations for NP_001288224.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC153910
      Consensus CDS
      CCDS20418.1
      UniProtKB/Swiss-Prot
      P56198, Q499X5, Q8BNV7
      Related
      ENSMUSP00000108712.2, ENSMUST00000113089.8
      Conserved Domains (1) summary
      cl02541
      Location:41120
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
    2. NM_001372264.1NP_001359193.1  lipid transferase CIDEC isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153910
      Consensus CDS
      CCDS90100.1
      UniProtKB/TrEMBL
      E9QMZ0
      Related
      ENSMUSP00000108714.2, ENSMUST00000113091.8
      Conserved Domains (1) summary
      cl02541
      Location:51130
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
    3. NM_178373.4NP_848460.1  lipid transferase CIDEC isoform 1

      See identical proteins and their annotated locations for NP_848460.1

      Status: VALIDATED

      Source sequence(s)
      AC153910, AK080133
      Consensus CDS
      CCDS20418.1
      UniProtKB/Swiss-Prot
      P56198, Q499X5, Q8BNV7
      Related
      ENSMUSP00000032416.5, ENSMUST00000032416.11
      Conserved Domains (1) summary
      cl02541
      Location:41120
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113401595..113412721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)