LCP1 lymphocyte cytosolic protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LCP1provided by HGNC
Official Full Name: lymphocyte cytosolic protein 1provided by HGNC
Primary source: HGNC:HGNC:6528
See related: Ensembl:ENSG00000136167 MIM:153430; AllianceGenome:HGNC:6528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN
Summary: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lymph node (RPKM 278.7), bone marrow (RPKM 256.8) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q14.13

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (46125923..46182177, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (45347305..45403192, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (46700058..46756312, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer.
Title: Targeted proteomics using parallel reaction monitoring confirms salivary proteins indicative of metastatic triple-negative breast cancer.
Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer.
Title: Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer.
LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer.
Title: LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer.
The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer.
Title: The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent in cancer.
Among the proteins found to preferentially bind clasped rather than the isolated alphaM and beta2 subunits was L-plastin (LCP1, also known as plastin-2), which binds to and maintains the inactive state of alphaMbeta2 integrin in vivo and thereby regulates leukocyte adhesion to integrin ligands under flow.
Title: LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.
LPL oxidation diminishes its actin-bundling capacity.
Title: Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.
LCP1-positive oral squamous cell carcnome samples were correlated closely with the primary tumor size and regional lymph node metastasis.
Title: Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.
MOLP8/R cells display a very high overexpression of LCP1 gene (l-Plastin) controlled by HIF1&alpha.
Title: Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy.
these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment.
Title: AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin.
Mutated LCP1 is a driver of chronic lymphocytic leukemia.
Title: Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of T-plastin and downregulates the expression of L-plastin in T-cell lines	PubMed
Envelope surface glycoprotein gp160, precursor	env	Plasmin cleaves HIV-1 gp160 precisely at the C-terminal arginine residue 510 of gp120, yielding the mature gp120 and gp41 proteins	PubMed
retropepsin	gag-pol	A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-D19729 (e-PCR)
- UniSTS:18953

WI-17631 (e-PCR)
- UniSTS:76422

RH17581 (e-PCR)
- UniSTS:49574

D10S2284 (e-PCR)
- UniSTS:30400

LCP1_894 (e-PCR)
- UniSTS:277448

Clone Names

FLJ25423, FLJ26114, FLJ39956, DKFZp781A23186

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in actin crosslink formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in wound healing, spreading of cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	IMP Inferred from Mutant Phenotype more info	PubMed
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament bundle	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell junction	TAS Traceable Author Statement more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in filopodium	IMP Inferred from Mutant Phenotype more info	PubMed
located_in focal adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in glial cell projection	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IMP Inferred from Mutant Phenotype more info	PubMed
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with stress fiber	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: plastin-2

Names: L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LCP-1; Lymphocyte cytosolic protein-1 (plasmin); bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); epididymis secretory protein Li 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002298.5 → NP_002289.2 plastin-2

See identical proteins and their annotated locations for NP_002289.2

Status: REVIEWED

Source sequence(s)

AY960627, BC007673, BF893502, DA820090, DB156931, J02923

Consensus CDS

CCDS9403.1

UniProtKB/Swiss-Prot

B2R613, B4DUA0, P13796, Q5TBN4

UniProtKB/TrEMBL

Q53FI1

Related

ENSP00000315757.2, ENST00000323076.7

Conserved Domains (5) summary

smart00033
Location:398 → 501

CH; Calponin homology domain

COG5069
Location:16 → 620

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00014
Location:121 → 236

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:13 → 79

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00307
Location:265 → 370

CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p14 Primary Assembly

Range

46125923..46182177 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005266374.3 → XP_005266431.1 plastin-2 isoform X1

See identical proteins and their annotated locations for XP_005266431.1

UniProtKB/Swiss-Prot

B2R613, B4DUA0, P13796, Q5TBN4

UniProtKB/TrEMBL

Q53FI1

Conserved Domains (5) summary

smart00033
Location:398 → 501

CH; Calponin homology domain

COG5069
Location:16 → 620

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00014
Location:121 → 236

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:13 → 79

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00307
Location:265 → 370

CH; Calponin homology (CH) domain
XM_047430303.1 → XP_047286259.1 plastin-2 isoform X1

UniProtKB/Swiss-Prot

B2R613, B4DUA0, P13796, Q5TBN4
XM_047430304.1 → XP_047286260.1 plastin-2 isoform X2
XM_047430305.1 → XP_047286261.1 plastin-2 isoform X3