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    Maged2 MAGE family member D2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113947, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Maged2provided by RGD
    Official Full Name
    MAGE family member D2provided by RGD
    Primary source
    RGD:70899
    See related
    Ensembl:ENSRNOG00000002449 AllianceGenome:RGD:70899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in female pregnancy; negative regulation of transcription by RNA polymerase II; and renal sodium ion absorption. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bartter disease type 5. Orthologous to human MAGED2 (MAGE family member D2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 811.2), Muscle (RPKM 214.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (23160928..23364994, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (19733593..19741769, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (33174539..33182715, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance complex component 2, pseudogene 1 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene ras homolog family member A, pseudogene 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene oligosaccharyltransferase complex non-catalytic subunit, pseudogene 1 Neighboring gene aminoacylase 1 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. Langnaese K, et al. Cytogenet Cell Genet, 2001. PMID 11856887
    2. Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. Laghmani K, et al. N Engl J Med, 2016 May 12. PMID 27120771
    3. Mammalian small nucleolar RNAs are mobile genetic elements. Weber MJ. PLoS Genet, 2006 Dec 8. PMID 17154719, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues
      Title: Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124946

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in renal sodium ion absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen D2
    Names
    melanoma antigen, family D, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271109.1 → NP_001258038.1  melanoma-associated antigen D2

      See identical proteins and their annotated locations for NP_001258038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC107467
      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1, Q9EPI7
      Conserved Domains (2) summary
      pfam01454
      Location:286 → 454
      MAGE; MAGE family
      NF033761
      Location:32 → 171
      gliding_GltJ; adventurous gliding motility protein GltJ

    2. NM_001271110.1 → NP_001258039.1  melanoma-associated antigen D2

      See identical proteins and their annotated locations for NP_001258039.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC107467, FM059132
      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1, Q9EPI7
      Conserved Domains (2) summary
      pfam01454
      Location:286 → 454
      MAGE; MAGE family
      NF033761
      Location:32 → 171
      gliding_GltJ; adventurous gliding motility protein GltJ

    3. NM_080479.2 → NP_536727.2  melanoma-associated antigen D2

      See identical proteins and their annotated locations for NP_536727.2

      Status: VALIDATED

      Source sequence(s)
      BC107467
      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1, Q9EPI7
      Conserved Domains (2) summary
      pfam01454
      Location:286 → 454
      MAGE; MAGE family
      NF033761
      Location:32 → 171
      gliding_GltJ; adventurous gliding motility protein GltJ

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      23160928..23364994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279730.1 → XP_063135800.1  melanoma-associated antigen D2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1

    2. XM_063279729.1 → XP_063135799.1  melanoma-associated antigen D2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1

    3. XM_017593115.3 → XP_017448604.1  melanoma-associated antigen D2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1, Q9EPI7
      Conserved Domains (2) summary
      pfam01454
      Location:286 → 454
      MAGE; MAGE family
      NF033761
      Location:32 → 171
      gliding_GltJ; adventurous gliding motility protein GltJ

    4. XM_006237924.5 → XP_006237986.1  melanoma-associated antigen D2 isoform X1

      See identical proteins and their annotated locations for XP_006237986.1

      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1, Q9EPI7
      Related
      ENSRNOP00000074736.1
      Conserved Domains (2) summary
      pfam01454
      Location:286 → 454
      MAGE; MAGE family
      NF033761
      Location:32 → 171
      gliding_GltJ; adventurous gliding motility protein GltJ

    5. XM_063279731.1 → XP_063135801.1  melanoma-associated antigen D2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8U1, Q3B7U1
    Nucleotide Protein Strain
    Heading Accession and Version

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