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    Tmpo thymopoietin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25359, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tmpoprovided by RGD
    Official Full Name
    thymopoietinprovided by RGD
    Primary source
    RGD:3875
    See related
    Ensembl:ENSRNOG00000008797 AllianceGenome:RGD:3875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LAP2
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within regulation of transcription, DNA-templated. Located in nuclear inner membrane. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 428.2), Spleen (RPKM 312.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmpo in Genome Data Viewer
    Location:
    7q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (27529977..27554980, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (25642752..25667756, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (31847412..31872416, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene IKBKB interacting protein Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene uncharacterized LOC134479859 Neighboring gene transfer RNA tryptophan (anticodon CCA) 1 Neighboring gene transfer RNA aspartic acid (anticodon GUC) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. Furukawa K, et al. EMBO J, 1995 Apr 18. PMID 7737115, Free PMC Article
    2. Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina. Bradley CM, et al. Structure, 2007 Jun. PMID 17562312
    3. Lap2alpha expression is controlled by E2F and deregulated in various human tumors. Parise P, et al. Cell Cycle, 2006 Jun. PMID 16760672
    4. Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. Yang L, et al. J Cell Biol, 1997 Jun 16. PMID 9182656, Free PMC Article
    5. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. Dechat T, et al. J Cell Sci, 2004 Dec 1. PMID 15546916

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
      Title: LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly.
    2. In agreement with its regulation by E2F, LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate
      Title: Lap2alpha expression is controlled by E2F and deregulated in various human tumors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear membrane reassembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lamina-associated polypeptide 2, isoform beta; lamina-associated polypeptide 2
    Names
    TP beta
    Thymopoietin (lamina associated polypeptide 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395714.1 → NP_001382643.1  lamina-associated polypeptide 2, isoform beta isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AFR4, A6IFV9
      Related
      ENSRNOP00000092044.1, ENSRNOT00000095834.1
      Conserved Domains (3) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam11560
      Location:459 → 691
      LAP2alpha; Lamina-associated polypeptide 2 alpha
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    2. NM_001395715.1 → NP_001382644.1  lamina-associated polypeptide 2, isoform beta isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6G2M4, A6IFV6
      Related
      ENSRNOP00000078350.1, ENSRNOT00000112365.1
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    3. NM_012887.2 → NP_037019.1  lamina-associated polypeptide 2, isoform beta isoform 2

      See identical proteins and their annotated locations for NP_037019.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q62733
      UniProtKB/TrEMBL
      A6IFV8
      Related
      ENSRNOP00000012715.4, ENSRNOT00000012715.5
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      27529977..27554980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765219.1 → XP_008763441.1  lamina-associated polypeptide 2 isoform X2

      See identical proteins and their annotated locations for XP_008763441.1

      UniProtKB/TrEMBL
      A0A8I5ZZ38, A6IFV7
      Related
      ENSRNOP00000084254.1, ENSRNOT00000097150.1
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    2. XM_039078463.1 → XP_038934391.1  lamina-associated polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADD0
      Related
      ENSRNOP00000090294.1, ENSRNOT00000111659.1
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62733.3 GenPept UniProtKB/Swiss-Prot:Q62733

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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