Pi4kb phosphatidylinositol 4-kinase beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pi4kbprovided by RGD
Official Full Name: phosphatidylinositol 4-kinase betaprovided by RGD
Primary source: RGD:621214
See related: Ensembl:ENSRNOG00000021024 AllianceGenome:RGD:621214
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pik4cb
Summary: Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Located in cytosol and plasma membrane. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 175.8), Kidney (RPKM 157.8) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185229392..185261697)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (182540377..182572684)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (196139724..196172055)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that the anti-inflammatory effects of sanguinarine on PtdIns 3-kinase signaling pathway are more likely an indirect effect and emphasize the importance of the cross talk between type II PtdIns 4-kinases and PtdIns 3-kinases.
Title: Sanguinarine suppresses IgE induced inflammatory responses through inhibition of type II PtdIns 4-kinase(s).
Work suggests an important role for both eEF1A2 and PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin remodeling.
Title: Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.
NCS-1 protein and 1-phosphatidylinositol 4-kinase b interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.
Title: Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.
functional implication of a NCS-1.PI4K-beta complex in regulated exocytosis in neurons
Title: Functional implication of neuronal calcium sensor-1 and phosphoinositol 4-kinase-beta interaction in regulated exocytosis of PC12 cells.
Overexpression of a PI4K beta mutant in rat mast cells inhibits IgE receptor-triggered phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and exocytosis.
Title: Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells.
there is a physical and functional relationship between eEF1A2 and PI4KIIIbeta
Title: Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation.
phosphatidylinositol-4 kinase in basolateral membranes from kidney cells is activated by sphingosine-1-phosphate
Title: Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH128413 (e-PCR)
- UniSTS:211721

D3Umi7 (e-PCR), detects polymorphism
- UniSTS:281106

RH142980 (e-PCR)
- UniSTS:232227

MARC_27466-27467:1034353260:1 (e-PCR)
- UniSTS:269094

REN33651 (e-PCR)
- UniSTS:358451

AA437822 (e-PCR), detects polymorphism
- UniSTS:143027

REN33561 (e-PCR)
- UniSTS:358361

RH144445 (e-PCR)
- UniSTS:233690

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol 4-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol 4-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol 4-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol 4-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 14-3-3 protein binding	IEA Inferred from Electronic Annotation more info
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: phosphatidylinositol 4-kinase beta

Names: PI4K-beta; PI4Kbeta; catalytic phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; ptdIns 4-kinase beta

NP_112345.1

EC 2.7.1.67

XP_008759555.1

EC 2.7.1.67

XP_038959158.1

EC 2.7.1.67

XP_038959159.1

EC 2.7.1.67

XP_038959160.1

EC 2.7.1.67

XP_038959161.1

EC 2.7.1.67

XP_038959162.1

EC 2.7.1.67

XP_038959163.1

EC 2.7.1.67

XP_063138702.1

EC 2.7.1.67

XP_063138703.1

EC 2.7.1.67

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031083.2 → NP_112345.1 phosphatidylinositol 4-kinase beta

See identical proteins and their annotated locations for NP_112345.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O08561

UniProtKB/TrEMBL

A0A8L2QJX4, A6K2T7

Related

ENSRNOP00000039342.2, ENSRNOT00000040501.3

Conserved Domains (2) summary

cd05168
Location:529 → 816

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

cd22246
Location:2 → 66

PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

185229392..185261697

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103230.2 → XP_038959158.1 phosphatidylinositol 4-kinase beta isoform X1

UniProtKB/TrEMBL

A0A8L2QJX4

Conserved Domains (2) summary

cd05168
Location:554 → 862

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

cd22246
Location:27 → 91

PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta
XM_008761333.4 → XP_008759555.1 phosphatidylinositol 4-kinase beta isoform X4

See identical proteins and their annotated locations for XP_008759555.1

UniProtKB/TrEMBL

A0A8I6ALD3, A0A8L2QJX4

Related

ENSRNOP00000093461.1

Conserved Domains (1) summary

cd05168
Location:554 → 841

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
XM_039103233.2 → XP_038959161.1 phosphatidylinositol 4-kinase beta isoform X3

UniProtKB/TrEMBL

A0A0G2JYH1

Conserved Domains (2) summary

cd05168
Location:539 → 847

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

cd22246
Location:27 → 91

PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta
XM_039103235.2 → XP_038959163.1 phosphatidylinositol 4-kinase beta isoform X6

UniProtKB/TrEMBL

A0A8I5ZT79, A0A8L2QJX4

Related

ENSRNOP00000082231.1

Conserved Domains (2) summary

cd05168
Location:539 → 826

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

cd22246
Location:27 → 91

PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta
XM_039103231.2 → XP_038959159.1 phosphatidylinositol 4-kinase beta isoform X1

UniProtKB/TrEMBL

A0A8L2QJX4

Conserved Domains (2) summary

cd05168
Location:554 → 862

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

cd22246
Location:27 → 91

PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta
XM_039103232.2 → XP_038959160.1 phosphatidylinositol 4-kinase beta isoform X2

UniProtKB/TrEMBL

A0A8L2QJX4

Conserved Domains (2) summary

cd05168
Location:542 → 850

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

cd22246
Location:15 → 79

PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta
XM_063282632.1 → XP_063138702.1 phosphatidylinositol 4-kinase beta isoform X7

UniProtKB/TrEMBL

A0A8I6ASK5, A0A8L2QJX4
XM_039103234.2 → XP_038959162.1 phosphatidylinositol 4-kinase beta isoform X5

UniProtKB/TrEMBL

A0A0G2JYH1, A0A8I6AD21

Related

ENSRNOP00000089657.1

Conserved Domains (2) summary

cd05168
Location:529 → 837

PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

cd22246
Location:2 → 66

PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta
XM_063282633.1 → XP_063138703.1 phosphatidylinositol 4-kinase beta isoform X8